miR miR on the wall, who's the most malignant medulloblastoma miR of them all?

microRNAs (miRNAs) have wide-ranging effects on large-scale gene regulation. As such, they play a vital role in dictating normal development, and their aberrant expression has been implicated in cancer. There has been a large body of research on the role of miRNAs in medulloblastoma, the most common...

Full description

Saved in:
Bibliographic Details
Published in:Neuro-oncology (Charlottesville, Va.) Va.), 2018-02, Vol.20 (3), p.313-323
Main Authors: Wang, Xin, Holgado, Borja L, Ramaswamy, Vijay, Mack, Stephen, Zayne, Kory, Remke, Marc, Wu, Xiaochong, Garzia, Livia, Daniels, Craig, Kenney, Anna M, Taylor, Michael D
Format: Article
Language:English
Subjects:
Biomarkers, Tumor - genetics
Cerebellar Neoplasms - diagnosis
Cerebellar Neoplasms - genetics
Editor's Choice
Gene Expression Regulation, Neoplastic
Humans
Medulloblastoma - diagnosis
Medulloblastoma - genetics
MicroRNAs - genetics
Prognosis
Reviews
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:microRNAs (miRNAs) have wide-ranging effects on large-scale gene regulation. As such, they play a vital role in dictating normal development, and their aberrant expression has been implicated in cancer. There has been a large body of research on the role of miRNAs in medulloblastoma, the most common malignant brain tumor of childhood. The identification of the 4 molecular subgroups with distinct biological, genetic, and transcriptional features has revolutionized the field of medulloblastoma research over the past 5 years. Despite this, the growing body of research on miRNAs in medulloblastoma has largely focused on the clinical entity of a single disease rather than the molecular subgroups. This review begins by highlighting the role of miRNAs in development and progresses to explore their myriad of implications in cancer. Medulloblastoma is characterized by increased proliferation, inhibition of apoptosis, and maintenance of stemness programs-features that are inadvertently regulated by altered expression patterns in miRNAs. This review aims to contextualize the large body of work on miRNAs within the framework of medulloblastoma subgroups. The goal of this review is to stimulate new areas of research, including potential therapeutics, within a rapidly growing field.
ISSN:1522-8517
1523-5866
DOI:10.1093/neuonc/nox106