Maternal thyroid function and child educational attainment: prospective cohort study

• Published in: BMJ (Online) 2018-02, Vol.360, p.k452-k452
• Main Authors: Nelson, Scott M, Haig, Caroline, McConnachie, Alex, Sattar, Naveed, Ring, Susan M, Smith, George D, Lawlor, Debbie A, Lindsay, Robert S
• Format: Article
• Language: English
• Subjects: Adolescent; Age; Child; Child, Preschool; Children; Children & youth; Cognitive ability; Cohort analysis; Educational attainment; Educational Status; Endocrinology; Female; Gestation; Hormones; Humans; Hyperthyroidism; Hypothyroidism; Intelligence - physiology; Iodide peroxidase; Iodide Peroxidase - metabolism; Iodine; Longitudinal Studies; Neurodevelopmental Disorders - epidemiology; Neurodevelopmental Disorders - etiology; Neurodevelopmental Disorders - physiopathology; Parents & parenting; Peroxidase; Pregnancy; Pregnancy Complications - epidemiology; Pregnancy Complications - physiopathology; Pregnancy Trimester, First; Premature birth; Prenatal Exposure Delayed Effects - epidemiology; Prenatal Exposure Delayed Effects - physiopathology; Prospective Studies; Thyroid; Thyroid Diseases - epidemiology; Thyroid Diseases - physiopathology; Thyroid Function Tests; Thyroid gland; Thyrotropin - metabolism; Thyroxine; Thyroxine - metabolism; United Kingdom - epidemiology; Womens health
• ISSN: 0959-8138; 1756-1833
• DOI: 10.1136/bmj.k452

AbstractObjectiveTo determine if first trimester maternal thyroid dysfunction is a critical determinant of child scholastic performance and overall educational attainment.DesignProspective cohort study.SettingAvon Longitudinal Study of Parents and Children cohort in the UK.Participants4615 mother-child pairs with an available first trimester sample (median 10 weeks gestation, interquartile range 8-12).ExposuresFree thyroxine, thyroid stimulating hormone, and thyroid peroxidase antibodies assessed as continuous measures and the seven clinical categories of maternal thyroid function.Main outcome measuresFive age-specific national curriculum assessments in 3580 children at entry stage assessment at 54 months, increasing up to 4461 children at their final school assessment at age 15.ResultsNo strong evidence of clinically meaningful associations of first trimester free thyroxine and thyroid stimulating hormone levels with entry stage assessment score or Standard Assessment Test scores at any of the key stages was found. Associations of maternal free thyroxine or thyroid stimulating hormone with the total number of General Certificates of Secondary Education (GCSEs) passed (range 0-16) were all close to the null: free thyroxine, rate ratio per pmol/L 1.00 (95% confidence interval 1.00 to 1.01); and thyroid stimulating hormone, rate ratio 0.98 (0.94 to 1.02). No important relationship was observed when more detailed capped scores of GCSEs allowing for both the number and grade of pass or when language, mathematics, and science performance were examined individually or when all educational assessments undertaken by an individual from school entry to leaving were considered. 200 (4.3%) mothers were newly identified as having hypothyroidism or subclinical hypothyroidism and 97 (2.1%) subclinical hyperthyroidism or hyperthyroidism. Children of mothers with thyroid dysfunction attained an equivalent number of GCSEs and equivalent grades as children of mothers with euthyroidism.ConclusionsMaternal thyroid dysfunction in early pregnancy does not have a clinically important association with impaired child performance at school or educational achievement.