Isolated extracranial intraosseous metastasis of an intracranial meningioma following bevacizumab therapy: Case report and review of the literature

Meningiomas account for a significant proportion of all primary intracranial tumors; distant metastasis is quite rare. We report a patient with resected, atypical meningioma. The patient's clinical course over 5 years included two craniotomies, a course of radiation, and a shortened course of b...

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Bibliographic Details
Published in:Asian journal of neurosurgery 2018-01, Vol.13 (1), p.98-101
Main Authors: Mukherjee, Debraj, Hu, Jethro, Chu, Ray
Format: Article
Language:English
Subjects:
Bevacizumab
Cancer metastasis
Care and treatment
Case Report
Complications and side effects
Dosage and administration
Magnetic resonance imaging
Meningioma
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Summary:Meningiomas account for a significant proportion of all primary intracranial tumors; distant metastasis is quite rare. We report a patient with resected, atypical meningioma. The patient's clinical course over 5 years included two craniotomies, a course of radiation, and a shortened course of bevacizumab. Only 5 months after starting bevacizumab, the patient developed an isolated left clavicular pathological fracture attributable to metastatic anaplastic meningioma. This constitutes the first report of meningioma with isolated extracranial intraosseous metastasis in the modern English literature and highlights concerns associated with the use of anti-angiogenic agents in promoting more invasive tumor phenotypes upon disease recurrence.
ISSN:1793-5482
2248-9614
DOI:10.4103/1793-5482.185057