Recent advances in the endocrinology of the sebaceous gland

The sebaceous gland, long considered an evolutionary relic with little-to-no physiological relevance in humans, has emerged in recent decades as a key orchestrator and contributor to many cutaneous functions. In addition to the classical physico-chemical barrier function of the skin against constant...

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Bibliographic Details
Published in:Dermato-endocrinology 2017, Vol.9 (1), p.e1361576-e1361576
Main Authors: Szöllősi, Attila G, Oláh, Attila, Bíró, Tamás, Tóth, Balázs István
Format: Article
Language:English
Subjects:
Acne
Androgens
Cell signaling
Dehydrogenases
Endocrinology
Enzymes
Estrogens
Hormones
Immunology
Lipids
Physiology
Review
Sebaceous gland
Skin
Stem cells
Steroids
Testosterone
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Summary:The sebaceous gland, long considered an evolutionary relic with little-to-no physiological relevance in humans, has emerged in recent decades as a key orchestrator and contributor to many cutaneous functions. In addition to the classical physico-chemical barrier function of the skin against constant environmental challenges, a more novel, neuro-immune modulatory role has also emerged. As part of the complex intercellular communication network of the integumentary system, the sebaceous gland acts as a "relay station" in the skin for many endocrine factors. This review aims to offer a comprehensive overview of endocrine effects and subsequent interactions on this much maligned mini-organ.
ISSN:1938-1972
1938-1980
1938-1980
DOI:10.1080/19381980.2017.1361576