Klotho ameliorates sepsis-induced acute kidney injury but is irrelevant to autophagy

The role of Klotho (KL) in sepsis-induced acute kidney injury (AKI) and the potential relationship between KL and autophagy in septic AKI were investigated. A murine model of sepsis-induced AKI was established by cecal ligation and puncture (CLP). Mice undergoing CLP and immortalized proximal tubula...

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Bibliographic Details
Published in:OncoTargets and therapy 2018-01, Vol.11, p.867-881
Main Authors: Chen, Xinxin, Tong, Huan, Chen, Yu, Chen, Chaosheng, Ye, Jingjing, Mo, Qingfei, Zhao, Guangju, Hong, Guangliang, Zheng, Chenfei, Lu, Zhongqiu
Format: Article
Language:English
Subjects:
Apoptosis
Autophagy
EDTA
Experiments
Gastric cancer
Gene expression
Hypoxia
Infection
Ischemia
Kidneys
Laboratory animals
Lipopolysaccharides
Liver cancer
Microscopy
Mitogens
Mortality
Nephrology
Original Research
Oxidative stress
Rapamycin
Rodents
Sepsis
Surgery
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Summary:The role of Klotho (KL) in sepsis-induced acute kidney injury (AKI) and the potential relationship between KL and autophagy in septic AKI were investigated. A murine model of sepsis-induced AKI was established by cecal ligation and puncture (CLP). Mice undergoing CLP and immortalized proximal tubular epithelial human HK-2 cells that were exposed to lipopolysaccharide (LPS) were treated with recombinant KL, autophagy stimulator rapamycin (Rap), and autophagy suppressor 3-methyladenine (3-MA). Autophagy activation and KL reduction reached maximum levels in mice 24 hours after CLP. Recombinant KL and/or Rap significantly attenuated CLP-induced renal dysfunction (
ISSN:1178-6930
1178-6930
DOI:10.2147/OTT.S156891