Auto- and cross-regulation of the hnRNPs D and DL

HnRNP D, better known as AUF1, is an extensively studied protein that controls a variety of cellular pathways. Consequently, its expression has to be tightly regulated to prevent the onset of pathologies. In contrast, the cellular functions and regulation of its ubiquitously expressed paralog hnRNP...

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Bibliographic Details
Published in:RNA (Cambridge) 2018-03, Vol.24 (3), p.324-331
Main Authors: Kemmerer, Katrin, Fischer, Sandra, Weigand, Julia E
Format: Article
Language:English
Subjects:
3' Untranslated Regions - genetics
Alternative Splicing
Exons
Gene Expression Regulation - genetics
Genes, Reporter
HeLa Cells
Heterogeneous-Nuclear Ribonucleoprotein D - genetics
Heterogeneous-Nuclear Ribonucleoprotein D - physiology
Heterogeneous-Nuclear Ribonucleoprotein L - genetics
Heterogeneous-Nuclear Ribonucleoproteins - genetics
Homeostasis
Humans
Nonsense Mediated mRNA Decay - genetics
Ribonucleoproteins - genetics
Ribonucleoproteins - physiology
RNA, Messenger - genetics
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Summary:HnRNP D, better known as AUF1, is an extensively studied protein that controls a variety of cellular pathways. Consequently, its expression has to be tightly regulated to prevent the onset of pathologies. In contrast, the cellular functions and regulation of its ubiquitously expressed paralog hnRNP DL are barely explored. Here, we present an intricate crosstalk between these two proteins. Both hnRNP D and DL are able to control their own expression by alternative splicing of cassette exons in their 3'UTRs. Exon inclusion produces mRNAs degraded by nonsense-mediated decay. Moreover, hnRNP D and DL control the expression of one another by the same mechanism. Thus, we identified two novel ways of how hnRNP D expression is controlled. The tight interconnection of expression control directly links hnRNP DL to hnRNP D-related diseases and emphasizes the importance of a systematic analysis of its cellular functions.
ISSN:1355-8382
1469-9001
DOI:10.1261/rna.063420.117