Antiplasmodial activity of two medicinal plants against clinical isolates of Plasmodium falciparum and Plasmodium berghei infected mice

Malaria is an infectious and deadly parasitic disease, associated with fever, anaemia and other ailments. Unfortunately the upsurge of plasmodium multidrug resistant constrained researchers to look for new effective drugs. Medicinal plants seem to be an unquenchable source of bioactive principles in...

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Bibliographic Details
Published in:Journal of parasitic diseases 2018-03, Vol.42 (1), p.68-76
Main Authors: Attemene, Serge David Dago, Beourou, Sylvain, Tuo, Karim, Gnondjui, Albert Alloh, Konate, Abibatou, Toure, Andre Offianan, Kati-Coulibaly, Seraphin, Djaman, Joseph Alico
Format: Article
Language:English
Subjects:
Antiprotozoal agents
Bark
Bioactive compounds
Bioassays
Body temperature
Body weight
Clinical isolates
Erythrocytes
Fever
Health Promotion and Disease Prevention
Herbal medicine
Infectious Diseases
Life Sciences
Malaria
Medicinal plants
Medicine
Medicine & Public Health
Multidrug resistance
Original
Original Article
Parasitemia
Plant extracts
Plasmodium berghei
Plasmodium falciparum
Studies
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Summary:Malaria is an infectious and deadly parasitic disease, associated with fever, anaemia and other ailments. Unfortunately the upsurge of plasmodium multidrug resistant constrained researchers to look for new effective drugs. Medicinal plants seem to be an unquenchable source of bioactive principles in the treatment of various diseases. The aim of this study was to assess the antiplasmodial activity of two Ivorian medicinal plants. The in vitro activity was evaluated against clinical isolates and Plasmodium falciparum K1 multidrug resistant strain using the fluorescence based SYBR green I assay. The in vivo bioassay was carried out using the classical 4 day suppressive and curative tests on Plasmodium berghei infected mice. Results showed that the in vitro bioassay of both plant extracts were found to exhibit a promising and moderate antiparasitic effects on clinical isolates (5 µg/mL 
ISSN:0971-7196
0975-0703
DOI:10.1007/s12639-017-0966-7