Association of obstructive sleep apnea with hypertension: A systematic review and meta-analysis

Obstructive sleep apnea (OSA) is a sleep disorder characterized as complete or partial upper airflow cessation during sleep. Although it has been widely accepted that OSA is a risk factor for the development of hypertension, the studies focusing on this topic revealed inconsistent results. We aimed...

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Published in:Journal of global health 2018-06, Vol.8 (1), p.010405-010405
Main Authors: Hou, Haifeng, Zhao, Yange, Yu, Wenqing, Dong, Hualei, Xue, Xiaotong, Ding, Jian, Xing, Weijia, Wang, Wei
Format: Article
Language:English
Subjects:
Age
Bias
Body mass index
Ethnicity
Global health
Humans
Hypertension
Hypertension - epidemiology
Meta-analysis
Risk Factors
Sleep apnea
Sleep Apnea, Obstructive - epidemiology
Statistical analysis
Studies
Systematic review
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Summary:Obstructive sleep apnea (OSA) is a sleep disorder characterized as complete or partial upper airflow cessation during sleep. Although it has been widely accepted that OSA is a risk factor for the development of hypertension, the studies focusing on this topic revealed inconsistent results. We aimed to clarify the association between OSA and hypertension, including essential and medication-resistant hypertension. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) was followed. PubMed and Embase databases were used for searching the relevant studies published up to December 31, 2016. A quantitative approach of meta-analysis was performed to estimate the pooled odds ratio (OR) and 95% confidence interval (CI). Twenty-six studies with 51 623 participants (28 314 men, 23 309 women; mean age 51.8 years) met inclusion criteria and were included in this study. Among them, six studies showed a significant association between OSA and resistant hypertension (pooled OR = 2.842, 95% CI = 1.703-3.980,  
ISSN:2047-2978
2047-2986
DOI:10.7189/jogh.08.010405