Maternal Exercise Improves the Metabolic Health of Adult Offspring

The intrauterine environment can modulate the course of development and confer an enduring effect on offspring health. The effects of maternal diet to impair offspring metabolic health are well established, but the effects of maternal exercise on offspring metabolic health have been less defined. Be...

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Bibliographic Details
Published in:Trends in endocrinology and metabolism 2018-03, Vol.29 (3), p.164-177
Main Authors: Harris, Johan E., Baer, Lisa A., Stanford, Kristin I.
Format: Article
Language:English
Subjects:
Adult
Adult Children
Animals
Exercise - physiology
Female
Humans
Maternal Health
Physical Conditioning, Animal - physiology
Pregnancy
Prenatal Exposure Delayed Effects - metabolism
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Summary:The intrauterine environment can modulate the course of development and confer an enduring effect on offspring health. The effects of maternal diet to impair offspring metabolic health are well established, but the effects of maternal exercise on offspring metabolic health have been less defined. Because physical exercise is a treatment for obesity and type 2 diabetes (T2D), maternal exercise is an appealing intervention to positively influence the intrauterine environment and improve the metabolic health of offspring. Recent research has provided insights into the effects of maternal exercise on the metabolic health of adult offspring, which is the focus of this review. Maternal exercise improves metabolic health in adult male and female offspring. Maternal exercise negates the detrimental effects of an impaired maternal diet on the metabolic health of the offspring. Maternal exercise before and during pregnancy is necessary to confer maximal beneficial effects to offspring.
ISSN:1043-2760
1879-3061
DOI:10.1016/j.tem.2018.01.003