Vaginal Candida spp. genomes from women with vulvovaginal candidiasis

Abstract Candida albicans is the predominant cause of vulvovaginal candidiasis (VVC). Little is known regarding the genetic diversity of Candida spp. in the vagina or the microvariations in strains over time that may contribute to the development of VVC. This study reports the draft genome sequences...

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Bibliographic Details
Published in:Pathogens and disease 2017-08, Vol.75 (6)
Main Authors: Bradford, L. Latéy, Chibucos, Marcus C., Ma, Bing, Bruno, Vincent, Ravel, Jacques
Format: Article
Language:English
Subjects:
Adaptation
Adult
Antifungal Agents - therapeutic use
Candida
Candida albicans
Candida albicans - classification
Candida albicans - drug effects
Candida albicans - genetics
Candida albicans - isolation & purification
Candida glabrata - classification
Candida glabrata - drug effects
Candida glabrata - genetics
Candida glabrata - isolation & purification
Candidiasis
Candidiasis, Vulvovaginal - diagnosis
Candidiasis, Vulvovaginal - drug therapy
Candidiasis, Vulvovaginal - microbiology
Female
Fungal infections
Gene sequencing
Genetic diversity
Genetic Variation
Genome, Fungal
Genomes
Humans
Longitudinal Studies
Phylogeny
Shortomics
Single-nucleotide polymorphism
Vagina
Vagina - microbiology
Whole Genome Sequencing
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Summary:Abstract Candida albicans is the predominant cause of vulvovaginal candidiasis (VVC). Little is known regarding the genetic diversity of Candida spp. in the vagina or the microvariations in strains over time that may contribute to the development of VVC. This study reports the draft genome sequences of four C. albicans and one C. glabrata strains isolated from women with VVC. An SNP-based whole-genome phylogeny indicates that these isolates are closely related; however, phylogenetic distances between them suggest that there may be genetic adaptations driven by unique host environments. These sequences will facilitate further comparative analyses and ultimately improve our understanding of genetic variation in isolates of Candida spp. that are associated with VVC. Clinical vaginal Candida genomes.
ISSN:2049-632X
2049-632X
DOI:10.1093/femspd/ftx061