Palladium‐Catalyzed Atom‐Transfer Radical Cyclization at Remote Unactivated C(sp3)−H Sites: Hydrogen‐Atom Transfer of Hybrid Vinyl Palladium Radical Intermediates

A novel mild, visible‐light‐induced palladium‐catalyzed hydrogen atom translocation/atom‐transfer radical cyclization (HAT/ATRC) cascade has been developed. This protocol involves a 1,5‐HAT process of previously unknown hybrid vinyl palladium radical intermediates, thus leading to iodomethyl carbo‐...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2018-03, Vol.57 (10), p.2712-2715
Main Authors: Ratushnyy, Maxim, Parasram, Marvin, Wang, Yang, Gevorgyan, Vladimir
Format: Article
Language:English
Subjects:
cyclizations
hydrogen-atom transfer
Intermediates
Palladium
photochemistry
radicals
Translocation
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Summary:A novel mild, visible‐light‐induced palladium‐catalyzed hydrogen atom translocation/atom‐transfer radical cyclization (HAT/ATRC) cascade has been developed. This protocol involves a 1,5‐HAT process of previously unknown hybrid vinyl palladium radical intermediates, thus leading to iodomethyl carbo‐ and heterocyclic structures. A rad transfer: A novel mild, visible‐light‐induced palladium‐catalyzed hydrogen atom translocation/atom‐transfer radical cyclization (HAT/ATRC) cascade has been developed. This protocol involves a 1,5‐HAT process of previously unknown hybrid vinyl palladium radical intermediates, thus leading to iodomethyl carbo‐ and heterocyclic structures.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201712775