Longitudinal changes in intraocular pressure and association with systemic factors and refractive error: Lingtou Eye Cohort Study

ObjectivesTo investigate the longitudinal changes in intraocular pressure (IOP) and its associations with refractive error and systemic determinants in a Chinese geriatric population.DesignProspective cohort study.SettingGuangzhou Government Servant Physical Check-up Center, Guangzhou, China.Partici...

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Bibliographic Details
Published in:BMJ open 2018-02, Vol.8 (2), p.e019416-e019416
Main Authors: Han, Xiaotong, Yang, Tangjian, Zhang, Jian, Yu, Sha, Guo, Xinxing, Yan, William, Hu, Yin, He, Mingguang
Format: Article
Language:English
Subjects:
Age
Age Factors
Aged
Aging - physiology
Biomechanics
Blood Glucose - metabolism
Blood Pressure
Body Mass Index
China
Cohort analysis
Cross-Sectional Studies
Diabetes
Eye examinations
Family medical history
Female
Glaucoma
Glaucoma - blood
Glaucoma - etiology
Humans
Hyperglycemia - blood
Hyperglycemia - complications
Hypertension - complications
Hypertension - physiopathology
Intraocular Pressure
Male
Metabolism
Middle Aged
Myopia - complications
Ophthalmology
Population
Prospective Studies
Refractive Errors
Risk Factors
Sex Factors
Tonometry, Ocular
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Summary:ObjectivesTo investigate the longitudinal changes in intraocular pressure (IOP) and its associations with refractive error and systemic determinants in a Chinese geriatric population.DesignProspective cohort study.SettingGuangzhou Government Servant Physical Check-up Center, Guangzhou, China.Participants4413 government employees aged no less than 40 years (41.9% female) attending annual physical and eye examinations were included in this study. The inclusion criterion was having attended the 2010 follow-up examination. The exclusion criteria include glaucoma or intraocular surgery history, IOP >21 mm Hg at any visit or without available IOP data at all visits from 2010 to 2014.Primary and secondary outcome measuresThe outcome measure was IOP at each follow-up visit from 2010 to 2014. Mixed-effect model was used to assess the relationship between longitudinal changes in IOP and potential risk factors.ResultsFor the 2653 participants who had available IOP data at both the 2010 and 2014 follow-up visits, the average change in IOP was an increase of 0.43 (95% CI 0.36 to 0.50) mm Hg. For the whole study population and in the optimised mixed model, there was a non-linear increase of IOP with age (P
ISSN:2044-6055
2044-6055
DOI:10.1136/bmjopen-2017-019416