MicroRNA-Mediated Regulation of HMGB1 in Human Hepatocellular Carcinoma

High-mobility group box 1 (HMGB1) is a potential therapeutic target and novel biomarker in a variety of malignant tumors, including hepatocellular carcinoma (HCC). More recently, a number of microRNAs (miRNAs) are identified as a class of regulators for broad control of HMGB1-mediated biological act...

Full description

Saved in:
Bibliographic Details
Published in:BioMed research international 2018-01, Vol.2018 (2018), p.1-10
Main Authors: Yan, Jianing, Cai, Xiujun, Ying, Shibo
Format: Article
Language:English
Subjects:
Animal models
Apoptosis
Biomarkers
Cell growth
Chromosomal proteins
Cytokines
Dihydrofolate reductase
Health aspects
Hepatitis
Hepatocellular carcinoma
Hepatoma
HMGB1 protein
Inflammation
Liver cancer
Medical prognosis
Metastasis
MicroRNA
MicroRNAs
miRNA
Mitochondrial DNA
Proteins
Regulators
Review
Ribonucleic acid
RNA
Rodents
Roles
Signaling
Tumorigenesis
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:High-mobility group box 1 (HMGB1) is a potential therapeutic target and novel biomarker in a variety of malignant tumors, including hepatocellular carcinoma (HCC). More recently, a number of microRNAs (miRNAs) are identified as a class of regulators for broad control of HMGB1-mediated biological actions in eukaryotic cells. In this review article we will describe representative miRNAs involved in regulating the HMGB1 signaling pathways in HCC cell lines and/or animal models. We also propose the possible mechanisms underlying the miRNA/HMGB1 axis and discuss the future clinical significance of miRNAs targeting HMGB1 molecule for HCC therapy.
ISSN:2314-6133
2314-6141
DOI:10.1155/2018/2754941