Acrylic Acid Plasma Coated 3D Scaffolds for Cartilage tissue engineering applications

The current generation of tissue engineered additive manufactured scaffolds for cartilage repair shows high potential for growing adult cartilage tissue. This study proposes two surface modification strategies based on non-thermal plasma technology for the modification of poly(ethylene oxide terepht...

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Bibliographic Details
Published in:Scientific reports 2018-03, Vol.8 (1), p.3830-15, Article 3830
Main Authors: Cools, Pieter, Mota, Carlos, Lorenzo-Moldero, Ivan, Ghobeira, Rouba, De Geyter, Nathalie, Moroni, Lorenzo, Morent, Rino
Format: Article
Language:English
Subjects:
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Acids
Acrylic acid
Acrylics
Carboxylic acids
Cartilage
Cell migration
Chondroblasts
Chondrogenesis
Helium
Humanities and Social Sciences
multidisciplinary
Polyethylene oxide
Polymers
Science
Science (multidisciplinary)
Tissue engineering
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Summary:The current generation of tissue engineered additive manufactured scaffolds for cartilage repair shows high potential for growing adult cartilage tissue. This study proposes two surface modification strategies based on non-thermal plasma technology for the modification of poly(ethylene oxide terephthalate/poly(butylene terephthalate) additive manufactured scaffolds to enhance their cell-material interactions. The first, plasma activation in a helium discharge, introduced non-specific polar functionalities. In the second approach, a carboxylic acid plasma polymer coating, using acrylic acid as precursor, was deposited throughout the scaffolds. Both surface modifications were characterized by significant changes in wettability, linked to the incorporation of new oxygen-containing functional groups. Their capacity for chondrogenesis was studied using ATDC5 chondroblasts as a model cell-line. The results demonstrate that the carboxylic acid-rich plasma coating had a positive effect on the generation of the glucoaminoglycans (GAG) matrix and stimulated the migration of cells throughout the scaffold. He plasma activation stimulated the formation of GAGs but did not stimulate the migration of chondroblasts throughout the scaffolds. Both plasma treatments spurred chondrogenesis by favoring GAG deposition. This leads to the overall conclusion that acrylic acid based plasma coatings exhibit potential as a surface modification technique for cartilage tissue engineering applications.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-018-22301-0