Review of the biologic and clinical significance of genetic mutations in angioimmunoblastic T‐cell lymphoma

Angioimmunoblastic T‐cell lymphoma (AITL) is an age‐related malignant lymphoma, characterized by immune system‐dysregulated symptoms. Recent sequencing studies have clarified the recurrent mutations in ras homology family member A (RHOA) and in genes encoding epigenetic regulators, tet methyl cytosi...

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Bibliographic Details
Published in:Cancer science 2018-03, Vol.109 (3), p.490-496
Main Authors: Fukumoto, Kota, Nguyen, Tran B., Chiba, Shigeru, Sakata‐Yanagimoto, Mamiko
Format: Article
Language:English
Subjects:
Age
angioimmunoblastic T‐cell lymphoma
Chemokines
Clinical significance
Cytokines
Cytosine
Dehydrogenases
Dioxygenase
DNA (Cytosine-5-)-Methyltransferases - genetics
DNA-Binding Proteins - genetics
Epigenesis, Genetic
epigenetic regulator
Epigenetics
Gene Regulatory Networks
Genes
Genetic Predisposition to Disease
Genotype & phenotype
Homology
Humans
Immune system
Immunoblastic Lymphadenopathy - genetics
Isocitrate dehydrogenase
Isocitrate Dehydrogenase - genetics
Kinases
Lymphocytes
Lymphoma
Lymphoma, T-Cell - genetics
Mitochondria
multistep and multilineage tumorigenesis
Mutation
Proteins
Proto-Oncogene Proteins - genetics
ras homology family member A
Receptors, Antigen, T-Cell - genetics
Review
rhoA GTP-Binding Protein - genetics
RhoA protein
Signal Transduction
T-cell lymphoma
Thematic Section: Cancer Genomics
Tumorigenesis
T‐cell receptor‐signaling
Vascular endothelial growth factor
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Description
Summary:Angioimmunoblastic T‐cell lymphoma (AITL) is an age‐related malignant lymphoma, characterized by immune system‐dysregulated symptoms. Recent sequencing studies have clarified the recurrent mutations in ras homology family member A (RHOA) and in genes encoding epigenetic regulators, tet methyl cytosine dioxygenase 2 (TET2), DNA methyl transferase 3 alpha (DNMT3A) and isocitrate dehydrogenase 2, mitochondrial (IDH2), as well as those related to the T‐cell receptor signaling pathway in AITL. In this review, we focus on how this genetic information has changed the understanding of the developmental process of AITL and will in future lead to individualized therapies for AITL patients. Recent progress in next‐generation sequencing has revealed the AITL specific genomic abnormalities in epigenetic regulators and TCR signaling. In this paper, we focused on the insights on how the biological and clinical aspects are linked to the genomic features of AITL.
ISSN:1347-9032
1349-7006
DOI:10.1111/cas.13393