Gadolinium-Free Cardiac MR Stress T1-Mapping to Distinguish Epicardial From Microvascular Coronary Disease

• Published in: Journal of the American College of Cardiology 2018-03, Vol.71 (9), p.957-968
• Main Authors: Liu, Alexander, Wijesurendra, Rohan S, Liu, Joanna M, Greiser, Andreas, Jerosch-Herold, Michael, Forfar, John C, Channon, Keith M, Piechnik, Stefan K, Neubauer, Stefan, Kharbanda, Rajesh K, Ferreira, Vanessa M
• Format: Article
• Language: English
• Subjects: Adenosine; Adult; Aged; Angina; Angina pectoris; Angina, Unstable - diagnostic imaging; Angina, Unstable - physiopathology; Arteries; Biomarkers; Blood; Blood flow; Blood volume; Cardiology; Cardiovascular disease; Contrast agents; Coronary Angiography - methods; Coronary artery; Coronary artery disease; Coronary Artery Disease - diagnostic imaging; Coronary Artery Disease - physiopathology; Coronary Circulation - physiology; Coronary vessels; Exercise Test - methods; Female; Gadolinium; Heart; Humans; Infarction; Ischemia; Magnetic resonance; Magnetic Resonance Imaging, Cine - methods; Male; Mapping; Medical imaging; Microvasculature; Middle Aged; Myocardium; NMR; Nuclear magnetic resonance; Perfusion; Pericardium - diagnostic imaging; Pericardium - physiopathology; Physiology; Radiation; Reactivity; Sensitivity; Stress; Stresses; Ventricle
• ISSN: 0735-1097; 1558-3597
• DOI: 10.1016/j.jacc.2017.11.071

Novel cardiac magnetic resonance (CMR) stress T1 mapping can detect ischemia and myocardial blood volume changes without contrast agents and may be a more comprehensive ischemia biomarker than myocardial blood flow. This study describes the performance of the first prospective validation of stress T1 mapping against invasive coronary measurements for detecting obstructive epicardial coronary artery disease (CAD), defined by fractional flow reserve (FFR