Evaluation of Analgesic and Anti-Inflammatory Activities of Water Extract of Galla Chinensis In Vivo Models

• Published in: Evidence-based complementary and alternative medicine 2018-01, Vol.2018 (2018), p.1-7
• Main Authors: Yue, Guizhou, Cui, Qiankun, Yang, Yi, He, Changliang, Yin, Lizi, Li, Lixia, Zou, Yuanfeng, Yin, Zhongqiong, Jia, Renyong, Song, Xu, Sun, Kai, Liang, Xiaoxia
• Format: Article
• Language: English
• Subjects: Acids; Analgesics; Analysis; Animal models; Animals; Anti-inflammatory agents; Anti-inflammatory drugs; Care and treatment; Carrageenan; Carrageenin; Cytokines; Drug dosages; Edema; Enzyme-linked immunosorbent assay; Herbal medicine; Immunology; Inflammation; Interleukin 10; Membrane permeability; Nitric-oxide synthase; Pain; Permeability; Physiology; Prostaglandin E2; Rats; Rhus chinensis; Rodents; Traditional Chinese medicine
• ISSN: 1741-427X; 1741-4288
• DOI: 10.1155/2018/6784032

Aim. Pain and inflammation are associated with many diseases in humans and animals. Galla Chinensis, a traditional Chinese medicine, has a variety of pharmacological properties. The purpose of this study was to evaluate analgesic and anti-inflammatory activities of Galla Chinensis through different animal models. Method. The analgesic activities were evaluated by hot-plate and writhing tests. The anti-inflammatory effects were assessed by ear edema, capillary permeability, and paw edema tests. The contents of cytokines (NO, iNOS, PGE2, and IL-10) in serum of rats in paw edema test were inspected by ELISA assays. Results. In the hot-plate test, Galla Chinensis could significantly extend pain threshold when compared to control group. The inhibitory rates of writhes ranged from 36.62% to 68.57% in Galla Chinensis-treated mice. Treatment with Galla Chinensis (1 and 0.5 g/kg) could significantly inhibit ear edema (47.45 and 36.91%, resp.; P < 0.01). Galla Chinensis (1 g/kg) had significant (P < 0.05) anti-inflammatory activity in capillary permeability test (29.04%). In carrageenan-induced edema test, the inhibitory rates were 43.71% and 44.07% (P < 0.01) at 1 h and 2 h after administration of Galla Chinensis (1 g/kg), respectively, and the levels of proinflammatory cytokines were significantly reduced. Conclusion. These results suggest that Galla Chinensis has analgesic and anti-inflammatory effects, which may be a candidate drug for the treatment of inflammation and pain.