Rhabdomyolysis: a rare complication of Hashimoto’s thyroiditis precipitated by statin therapy

Hashimoto’s thyroiditis (HT) or chronic lymphocytic thyroiditis is the most common form of primary hypothyroidism. Muscular manifestations like weakness, pain, stiffness and elevated muscle enzymes have been noticed in hypothyroidism. Statins are also known to cause myositis and rhabdomyolysis. This...

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Bibliographic Details
Published in:BMJ case reports 2018-02, Vol.2018, p.bcr-2017-223229
Main Authors: Peringat, Jayameena, Manappallil, Robin George, Karadan, Ummer
Format: Article
Language:English
Subjects:
Alcohol
Anemia
Body mass index
Case reports
Diabetes
Edema
Enzymes
Fluid Therapy
Hashimoto Disease - complications
Hashimoto Disease - drug therapy
Hashimoto Disease - physiopathology
Health risk assessment
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage
Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects
Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
Hypothyroidism
Inflammatory diseases
Infusions, Intravenous
Kidneys
Lipoproteins
Male
Metabolism
Middle Aged
Musculoskeletal diseases
Pain
Reminder of Important Clinical Lesson
Rhabdomyolysis - chemically induced
Rhabdomyolysis - physiopathology
Statins
Thyroid gland
Thyroxine - therapeutic use
Trauma
Treatment Outcome
Ultrasonic imaging
Urine
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Description
Summary:Hashimoto’s thyroiditis (HT) or chronic lymphocytic thyroiditis is the most common form of primary hypothyroidism. Muscular manifestations like weakness, pain, stiffness and elevated muscle enzymes have been noticed in hypothyroidism. Statins are also known to cause myositis and rhabdomyolysis. This is a case of a middle-aged man, on statin therapy, who presented with severe muscle aches and pain and was found to have rhabdomyolysis. Further evaluation revealed an underlying HT as the culprit for his condition. He was managed with intravenous fluids and levothyroxine along with cessation of statins, following which he improved.
ISSN:1757-790X
1757-790X
DOI:10.1136/bcr-2017-223229