Clinical associations of total kidney volume: the Framingham Heart Study

Total kidney volume (TKV) is an imaging biomarker that may have diagnostic and prognostic utility. The relationships between kidney volume, renal function and cardiovascular disease (CVD) have not been characterized in a large community-dwelling population. This information is needed to advance the...

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Published in:Nephrology, dialysis, transplantation dialysis, transplantation, 2017-08, Vol.32 (8), p.1344-1350
Main Authors: Roseman, Daniel A, Hwang, Shih-Jen, Oyama-Manabe, Noriko, Chuang, Michael L, O'Donnell, Christopher J, Manning, Warren J, Fox, Caroline S
Format: Article
Language:English
Subjects:
Aged
Albuminuria - etiology
Albuminuria - pathology
Cardiovascular Diseases - complications
Case-Control Studies
Cross-Sectional Studies
Disease Progression
Female
Glomerular Filtration Rate
Humans
Kidney - pathology
Kidney Diseases - etiology
Kidney Diseases - pathology
Longitudinal Studies
Magnetic Resonance Imaging
Male
Middle Aged
Original
Prognosis
Risk Factors
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Summary:Total kidney volume (TKV) is an imaging biomarker that may have diagnostic and prognostic utility. The relationships between kidney volume, renal function and cardiovascular disease (CVD) have not been characterized in a large community-dwelling population. This information is needed to advance the clinical application of TKV. We measured TKV in 1852 Framingham Heart Study participants (mean age 64.1 ± 9.2 years, 53% women) using magnetic resonance imaging. A healthy sample was used to define reference values. The associations between TKV, renal function and CVD risk factors were determined using multivariable logistic regression analysis. Overall, mean TKV was 278 ± 54 cm3 for women and 365 ± 66 cm3 for men. Risk factors for high TKV (>90% healthy referent size) were body surface area (BSA), diabetes, smoking and albuminuria, while age, female and estimated glomerular filtration rate (eGFR)
ISSN:0931-0509
1460-2385
DOI:10.1093/ndt/gfw237