Imaging and histological appearance of pleomorphic hyalinizing angiectatic tumors: A case series and literature review

Pleomorphic hyalinizing angiectatic tumors (PHATs) are rare mesenchymal soft tissue tumors of uncertain lineage and intermediate malignancy. The present study assesses two cases of PHAT and discusses the histological and immunophenotypical features, as well as the imaging appearance of these tumors...

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Bibliographic Details
Published in:Oncology letters 2018-04, Vol.15 (4), p.4720-4730
Main Authors: Jaramillo, Couger Jimenez, Wojcik, John, Weber, Kristy, Sebro, Ronnie
Format: Article
Language:English
Subjects:
Antigens
Cancer recurrence
Cancer research
Care and treatment
Development and progression
Medical imaging
Microscopy
NMR
Nuclear magnetic resonance
Oncology
Pain
Risk factors
Sarcoma
Tumors
Ultrasonic imaging
Veins & arteries
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Summary:Pleomorphic hyalinizing angiectatic tumors (PHATs) are rare mesenchymal soft tissue tumors of uncertain lineage and intermediate malignancy. The present study assesses two cases of PHAT and discusses the histological and immunophenotypical features, as well as the imaging appearance of these tumors on ultrasound, computed tomography (CT), magnetic resonance imaging and positron emission tomography/CT scans. The current study also reviews the literature and discusses the clinical management of these tumors. Wide local excision with tumor free margins is the current recommended treatment for PHAT. Surgical excision may be combined with low-dose radiation to reduce the risk of local recurrence. Patients should be followed up with serial imaging, as PHAT lesions tend to recur locally.
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2018.7929