Potential for a booster dose of rotavirus vaccine to further reduce diarrhea mortality

Concern has grown that children vaccinated against rotavirus in developing countries may be vulnerable to rotavirus diarrhea in the second year of life due to waning immunity. Adding a booster dose of rotavirus vaccine at 9 or 12 months of age with measles vaccine has been suggested as a strategy to...

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Bibliographic Details
Published in:Vaccine 2017-12, Vol.35 (51), p.7198-7203
Main Authors: Burnett, Eleanor, Lopman, Ben A., Parashar, Umesh D.
Format: Article
Language:English
Subjects:
Age
Births
Booster dose
Child mortality
Children
Children & youth
Cost-Benefit Analysis
Data points
Developing countries
Developing Countries - statistics & numerical data
Diarrhea
Diarrhea - mortality
Diarrhea - prevention & control
Estimates
Fatalities
Female
Humans
Immunity
Immunization, Secondary
Infant
Infant, Newborn
LDCs
Licensed products
Licenses
Literature reviews
Low income groups
Male
Measles
Models, Statistical
Mortality
Parameter uncertainty
Rotavirus
Rotavirus - immunology
Rotavirus Infections - immunology
Rotavirus Infections - prevention & control
Rotavirus vaccine
Rotavirus Vaccines - administration & dosage
Rotavirus Vaccines - immunology
Rubella
Systematic review
Vaccination
Vaccination - economics
Vaccination - methods
Vaccination Coverage
Vaccines
Vaccines, Attenuated - administration & dosage
Vaccines, Attenuated - immunology
Viruses
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Description
Summary:Concern has grown that children vaccinated against rotavirus in developing countries may be vulnerable to rotavirus diarrhea in the second year of life due to waning immunity. Adding a booster dose of rotavirus vaccine at 9 or 12 months of age with measles vaccine has been suggested as a strategy to address this. We evaluated the hypothetical potential benefits of a booster dose on reduction of rotavirus mortality. The projected number of deaths averted were calculated using national level full series vaccination coverage, estimated national rotavirus deaths by week of age, and VE at
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2017.10.027