Zofenopril and ramipril in patients with left ventricular systolic dysfunction after acute myocardial infarction: A propensity analysis of the Survival of Myocardial Infarction Long-term Evaluation (SMILE) 4 study

Introduction: This was a propensity score analysis of the prospective, randomized, double-blind Survival of Myocardial Infarction Long-term Evaluation (SMILE) 4 study in which one-year treatment with zofenopril 60 mg plus acetylsalicylic acid (ASA) 100 mg gave superior results compared to ramipril 1...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the renin-angiotensin-aldosterone system 2016-10, Vol.17 (4)
Main Authors: Borghi, Claudio, Omboni, Stefano, Novo, Salvatore, Vinereanu, Dragos, Ambrosio, Giuseppe, Ambrosioni, Ettore
Format: Article
Language:English
Subjects:
Captopril - analogs & derivatives
Captopril - therapeutic use
Demography
Drug Therapy, Combination
Endpoint Determination
Female
Hospitalization
Humans
Intention to Treat Analysis
Male
Middle Aged
Myocardial Infarction - complications
Myocardial Infarction - drug therapy
Myocardial Infarction - mortality
Myocardial Infarction - physiopathology
Original
Propensity Score
Ramipril - therapeutic use
Survival Analysis
Time Factors
Ventricular Dysfunction, Left - complications
Ventricular Dysfunction, Left - drug therapy
Ventricular Dysfunction, Left - physiopathology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Introduction: This was a propensity score analysis of the prospective, randomized, double-blind Survival of Myocardial Infarction Long-term Evaluation (SMILE) 4 study in which one-year treatment with zofenopril 60 mg plus acetylsalicylic acid (ASA) 100 mg gave superior results compared to ramipril 10 mg plus ASA in terms of death or hospitalization for cardiovascular causes in patients with acute myocardial infarction (AMI) complicated by left ventricular dysfunction (LVD). Materials and methods: A total of 716 patients of the intention-to-treat population were divided into homogeneous propensity quintiles (Q) using a logistic regression model (QI: best risk profile; QV: worst risk profile). Results: Treatment was associated with a similar low rate of major cardiovascular events in any Q. However, the efficacy of zofenopril was better than that of ramipril in QII, QV, and particularly QIII (odds ratio (OR) and 95% confidence interval: 0.43 (0.21–0.87), p
ISSN:1470-3203
1752-8976
DOI:10.1177/1470320316656480