The normality of sperm in an infertile man with ring chromosome 15: a case report

Purpose The purpose of this report is to analyze the chromosome status and fertilization capability of sperm obtained from an infertile male patient with ring chromosome 15. Methods This was a case report at a private in vitro fertilization clinic. A man diagnosed with severe oligozoospermia carryin...

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Bibliographic Details
Published in:Journal of assisted reproduction and genetics 2018-02, Vol.35 (2), p.251-256
Main Authors: Nishikawa, Kazuyo, Itoi, Fumiaki, Nagahara, Miki, Jose, Mami, Matsunaga, Ayumi, Ueda, Jun, Iwamoto, Takashi
Format: Article
Language:English
Subjects:
Animals
Case reports
Chromosome 15
Chromosomes
Chromosomes, Human, Pair 15
Female
Fertilization in Vitro
Gamete Biology
Gynecology
Human Genetics
Humans
In vitro fertilization
Infertility, Male - genetics
Karyotypes
Karyotyping
Male
Medicine
Medicine & Public Health
Mice, Inbred Strains
Mosaicism
Oligozoospermia
Oocytes
Reproductive Medicine
Ring Chromosomes
Sperm
Sperm Injections, Intracytoplasmic - methods
Spermatozoa - physiology
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Summary:Purpose The purpose of this report is to analyze the chromosome status and fertilization capability of sperm obtained from an infertile male patient with ring chromosome 15. Methods This was a case report at a private in vitro fertilization clinic. A man diagnosed with severe oligozoospermia carrying ring chromosome 15. To evaluate the chromosome status and fertilization capability, sperm from a patient carrying ring chromosome 15 were injected into enucleated mouse oocytes. Results The karyotypes of motile sperm from a patient carrying ring chromosome 15 were normal, and ring chromosome 15 was not observed in the chromosome spread samples of 1PN. In addition, these motile sperm retained the fertilization capability. However, the fertilization rates decreased (85.2, 76.2, and 64.3%, respectively) along with the decline of the aspect ratio of the sperm head (≥ 1.50, 1.30–1.49, and
ISSN:1058-0468
1573-7330
DOI:10.1007/s10815-017-1061-9