Cardiac macrophage biology in the steady-state heart, the aging heart, and following myocardial infarction

Macrophages play critical roles in homeostatic maintenance of the myocardium under normal conditions and in tissue repair after injury. In the steady-state heart, resident cardiac macrophages remove senescent and dying cells and facilitate electrical conduction. In the aging heart, the shift in macr...

Full description

Saved in:
Bibliographic Details
Published in:Translational research : the journal of laboratory and clinical medicine 2018-01, Vol.191, p.15-28
Main Authors: Ma, Yonggang, Mouton, Alan J., Lindsey, Merry L.
Format: Article
Language:English
Subjects:
Aging - physiology
Biomarkers - metabolism
Heart - physiology
Humans
Macrophages - pathology
Macrophages - physiology
Myocardial Infarction - pathology
Myocardium - pathology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Macrophages play critical roles in homeostatic maintenance of the myocardium under normal conditions and in tissue repair after injury. In the steady-state heart, resident cardiac macrophages remove senescent and dying cells and facilitate electrical conduction. In the aging heart, the shift in macrophage phenotype to a proinflammatory subtype leads to inflammaging. Following myocardial infarction (MI), macrophages recruited to the infarct produce both proinflammatory and anti-inflammatory mediators (cytokines, chemokines, matrix metalloproteinases, and growth factors), phagocytize dead cells, and promote angiogenesis and scar formation. These diverse properties are attributed to distinct macrophage subtypes and polarization status. Infarct macrophages exhibit a proinflammatory M1 phenotype early and become polarized toward an anti-inflammatory M2 phenotype later post-MI. Although this classification system is oversimplified and needs to be refined to accommodate the multiple different macrophage subtypes that have been recently identified, general concepts on macrophage roles are independent of subtype classification. This review summarizes current knowledge about cardiac macrophage origins, roles, and phenotypes in the steady state, with aging, and after MI, as well as highlights outstanding areas of investigation.
ISSN:1931-5244
1878-1810
DOI:10.1016/j.trsl.2017.10.001