Aberrant pro-atrial natriuretic peptide/corin/natriuretic peptide receptor signaling is present in maternal vascular endothelium in preeclampsia

•Maternal levels of pro-ANP and its converting enzyme corin are elevated in PE.•Upregulation of NPR-C expression suggests increased ANP clearance/degradation in PE.•Aberrant pro-ANP/corin/NPR signaling may contribute to vascular dysfunction in PE. Corin is a serine protease that converts pro-atrial...

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Published in:Pregnancy hypertension 2018-01, Vol.11, p.1-6
Main Authors: Gu, Yang, Thompson, Donna, Xu, Jie, Lewis, David F., Morgan, John A., Cooper, Danielle B., McCathran, Charles E., Wang, Yuping
Format: Article
Language:English
Subjects:
Adolescent
Adult
ANP
Atrial Natriuretic Factor - blood
Corin
Endothelium, Vascular - chemistry
Endothelium, Vascular - physiopathology
Female
Humans
NPR
Pre-Eclampsia - blood
Pre-Eclampsia - diagnosis
Pre-Eclampsia - physiopathology
Preeclampsia
Pregnancy
Receptors, Atrial Natriuretic Factor - analysis
Serine Endopeptidases - blood
Signal Transduction
Young Adult
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Summary:•Maternal levels of pro-ANP and its converting enzyme corin are elevated in PE.•Upregulation of NPR-C expression suggests increased ANP clearance/degradation in PE.•Aberrant pro-ANP/corin/NPR signaling may contribute to vascular dysfunction in PE. Corin is a serine protease that converts pro-atrial natriuretic peptide (pro-ANP) to atrial natriuretic peptide (ANP), a cardiac hormone that regulates salt-water balance and blood pressure. ANP is degraded by natriuretic peptide receptor (NPR). This study was to determine if aberrant pro-ANP/corin/NPR signaling is present in maternal vascular system in preeclampsia. Maternal venous blood was obtained from 197 pregnant women (84 normotensive, 16 complicated with chronic hypertension (CHT), 11 mild and 86 severe preeclampsia). Plasma corin and pro-ANP concentrations were measured by enzyme-linked immunosorbent assay. Maternal subcutaneous fat tissue was obtained from 12 pregnant women with cesarean section delivery (6 normotensive and 6 preeclampsia). Vascular ANP and its receptors NPR-A, NPR-B, and NPR-C expression were examined by immunostaining of paraffin embedded subcutaneous fat tissue sections. Corin concentrations were significantly higher in mild (2.78 ± 0.67 ng/ml, p 
ISSN:2210-7789
2210-7797
DOI:10.1016/j.preghy.2017.12.001