Aberrant pro-atrial natriuretic peptide/corin/natriuretic peptide receptor signaling is present in maternal vascular endothelium in preeclampsia

•Maternal levels of pro-ANP and its converting enzyme corin are elevated in PE.•Upregulation of NPR-C expression suggests increased ANP clearance/degradation in PE.•Aberrant pro-ANP/corin/NPR signaling may contribute to vascular dysfunction in PE. Corin is a serine protease that converts pro-atrial...

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Published in:Pregnancy hypertension 2018-01, Vol.11, p.1-6
Main Authors: Gu, Yang, Thompson, Donna, Xu, Jie, Lewis, David F., Morgan, John A., Cooper, Danielle B., McCathran, Charles E., Wang, Yuping
Format: Article
Language:English
Subjects:
Adolescent
Adult
ANP
Atrial Natriuretic Factor - blood
Corin
Endothelium, Vascular - chemistry
Endothelium, Vascular - physiopathology
Female
Humans
NPR
Pre-Eclampsia - blood
Pre-Eclampsia - diagnosis
Pre-Eclampsia - physiopathology
Preeclampsia
Pregnancy
Receptors, Atrial Natriuretic Factor - analysis
Serine Endopeptidases - blood
Signal Transduction
Young Adult
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container_title Pregnancy hypertension
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Wang, Yuping
description •Maternal levels of pro-ANP and its converting enzyme corin are elevated in PE.•Upregulation of NPR-C expression suggests increased ANP clearance/degradation in PE.•Aberrant pro-ANP/corin/NPR signaling may contribute to vascular dysfunction in PE. Corin is a serine protease that converts pro-atrial natriuretic peptide (pro-ANP) to atrial natriuretic peptide (ANP), a cardiac hormone that regulates salt-water balance and blood pressure. ANP is degraded by natriuretic peptide receptor (NPR). This study was to determine if aberrant pro-ANP/corin/NPR signaling is present in maternal vascular system in preeclampsia. Maternal venous blood was obtained from 197 pregnant women (84 normotensive, 16 complicated with chronic hypertension (CHT), 11 mild and 86 severe preeclampsia). Plasma corin and pro-ANP concentrations were measured by enzyme-linked immunosorbent assay. Maternal subcutaneous fat tissue was obtained from 12 pregnant women with cesarean section delivery (6 normotensive and 6 preeclampsia). Vascular ANP and its receptors NPR-A, NPR-B, and NPR-C expression were examined by immunostaining of paraffin embedded subcutaneous fat tissue sections. Corin concentrations were significantly higher in mild (2.78 ± 0.67 ng/ml, p 
doi_str_mv 10.1016/j.preghy.2017.12.001
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Corin is a serine protease that converts pro-atrial natriuretic peptide (pro-ANP) to atrial natriuretic peptide (ANP), a cardiac hormone that regulates salt-water balance and blood pressure. ANP is degraded by natriuretic peptide receptor (NPR). This study was to determine if aberrant pro-ANP/corin/NPR signaling is present in maternal vascular system in preeclampsia. Maternal venous blood was obtained from 197 pregnant women (84 normotensive, 16 complicated with chronic hypertension (CHT), 11 mild and 86 severe preeclampsia). Plasma corin and pro-ANP concentrations were measured by enzyme-linked immunosorbent assay. Maternal subcutaneous fat tissue was obtained from 12 pregnant women with cesarean section delivery (6 normotensive and 6 preeclampsia). Vascular ANP and its receptors NPR-A, NPR-B, and NPR-C expression were examined by immunostaining of paraffin embedded subcutaneous fat tissue sections. Corin concentrations were significantly higher in mild (2.78 ± 0.67 ng/ml, p &lt; .05) and severe (2.53 ± 0.18 ng/ml, p &lt; .01) preeclampsia than in normotensive (1.58 ± 0.08 ng/ml) and CHT (1.55 ± 0.20 ng/ml) groups. Pro-ANP concentrations were significantly higher in CHT (1.59 ± 0.53 ng/ml, p &lt; .05) and severe preeclampsia (1.42 ± 0.24 ng/ml, p &lt; .01) than in normotensive (0.48 ± 0.06 ng/ml) and mild preeclampsia (0.52 ± 0.09 ng/ml) groups. ANP and NPR-B expression was undetectable in maternal vessels from normotensive and preeclamptic pregnancies, but reduced NPR-A expression and increased NPR-C expression was found in maternal vessel endothelium in preeclampsia. ANP is a vasodilator and NPR-C is a clearance receptor for ANP. The finding of upregulation of NPR-C expression suggests that circulating ANP clearance or degradation is increased in preeclampsia. These results also suggest that pro-ANP/corin/NPR signaling is dominant in the vascular system in preeclampsia.</description><identifier>ISSN: 2210-7789</identifier><identifier>EISSN: 2210-7797</identifier><identifier>DOI: 10.1016/j.preghy.2017.12.001</identifier><identifier>PMID: 29523263</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adolescent ; Adult ; ANP ; Atrial Natriuretic Factor - blood ; Corin ; Endothelium, Vascular - chemistry ; Endothelium, Vascular - physiopathology ; Female ; Humans ; NPR ; Pre-Eclampsia - blood ; Pre-Eclampsia - diagnosis ; Pre-Eclampsia - physiopathology ; Preeclampsia ; Pregnancy ; Receptors, Atrial Natriuretic Factor - analysis ; Serine Endopeptidases - blood ; Signal Transduction ; Young Adult</subject><ispartof>Pregnancy hypertension, 2018-01, Vol.11, p.1-6</ispartof><rights>2017</rights><rights>Published by Elsevier B.V.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c463t-ceeff8f967867e7752c72bd405a512e3fa92923c9b6c49e7310503a192388ea03</citedby><cites>FETCH-LOGICAL-c463t-ceeff8f967867e7752c72bd405a512e3fa92923c9b6c49e7310503a192388ea03</cites><orcidid>0000-0002-8676-7549</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29523263$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gu, Yang</creatorcontrib><creatorcontrib>Thompson, Donna</creatorcontrib><creatorcontrib>Xu, Jie</creatorcontrib><creatorcontrib>Lewis, David F.</creatorcontrib><creatorcontrib>Morgan, John A.</creatorcontrib><creatorcontrib>Cooper, Danielle B.</creatorcontrib><creatorcontrib>McCathran, Charles E.</creatorcontrib><creatorcontrib>Wang, Yuping</creatorcontrib><title>Aberrant pro-atrial natriuretic peptide/corin/natriuretic peptide receptor signaling is present in maternal vascular endothelium in preeclampsia</title><title>Pregnancy hypertension</title><addtitle>Pregnancy Hypertens</addtitle><description>•Maternal levels of pro-ANP and its converting enzyme corin are elevated in PE.•Upregulation of NPR-C expression suggests increased ANP clearance/degradation in PE.•Aberrant pro-ANP/corin/NPR signaling may contribute to vascular dysfunction in PE. Corin is a serine protease that converts pro-atrial natriuretic peptide (pro-ANP) to atrial natriuretic peptide (ANP), a cardiac hormone that regulates salt-water balance and blood pressure. ANP is degraded by natriuretic peptide receptor (NPR). This study was to determine if aberrant pro-ANP/corin/NPR signaling is present in maternal vascular system in preeclampsia. Maternal venous blood was obtained from 197 pregnant women (84 normotensive, 16 complicated with chronic hypertension (CHT), 11 mild and 86 severe preeclampsia). Plasma corin and pro-ANP concentrations were measured by enzyme-linked immunosorbent assay. Maternal subcutaneous fat tissue was obtained from 12 pregnant women with cesarean section delivery (6 normotensive and 6 preeclampsia). Vascular ANP and its receptors NPR-A, NPR-B, and NPR-C expression were examined by immunostaining of paraffin embedded subcutaneous fat tissue sections. Corin concentrations were significantly higher in mild (2.78 ± 0.67 ng/ml, p &lt; .05) and severe (2.53 ± 0.18 ng/ml, p &lt; .01) preeclampsia than in normotensive (1.58 ± 0.08 ng/ml) and CHT (1.55 ± 0.20 ng/ml) groups. Pro-ANP concentrations were significantly higher in CHT (1.59 ± 0.53 ng/ml, p &lt; .05) and severe preeclampsia (1.42 ± 0.24 ng/ml, p &lt; .01) than in normotensive (0.48 ± 0.06 ng/ml) and mild preeclampsia (0.52 ± 0.09 ng/ml) groups. ANP and NPR-B expression was undetectable in maternal vessels from normotensive and preeclamptic pregnancies, but reduced NPR-A expression and increased NPR-C expression was found in maternal vessel endothelium in preeclampsia. ANP is a vasodilator and NPR-C is a clearance receptor for ANP. The finding of upregulation of NPR-C expression suggests that circulating ANP clearance or degradation is increased in preeclampsia. These results also suggest that pro-ANP/corin/NPR signaling is dominant in the vascular system in preeclampsia.</description><subject>Adolescent</subject><subject>Adult</subject><subject>ANP</subject><subject>Atrial Natriuretic Factor - blood</subject><subject>Corin</subject><subject>Endothelium, Vascular - chemistry</subject><subject>Endothelium, Vascular - physiopathology</subject><subject>Female</subject><subject>Humans</subject><subject>NPR</subject><subject>Pre-Eclampsia - blood</subject><subject>Pre-Eclampsia - diagnosis</subject><subject>Pre-Eclampsia - physiopathology</subject><subject>Preeclampsia</subject><subject>Pregnancy</subject><subject>Receptors, Atrial Natriuretic Factor - analysis</subject><subject>Serine Endopeptidases - blood</subject><subject>Signal Transduction</subject><subject>Young Adult</subject><issn>2210-7789</issn><issn>2210-7797</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9UduKFDEQbURxl3X_QCSPvnRPLt2dzouwLN5gwRd9Dpl09UwN6aRN0gP7F36yGWYdFcQQqKLqnFOVnKp6zWjDKOs3h2aJsNs_Npwy2TDeUMqeVdecM1pLqeTzSz6oq-o2pQMtp-3oIPuX1RVXHRe8F9fVj7stxGh8JksMtckRjSP-FNcIGS1ZYMk4wsaGiH7zjw6JYEsWIkm488ah3xFMRQ4SFFn0ZDYZYumQo0l2dSYS8GPIe3C4zidAwYJ1Zl4SmlfVi8m4BLdP8ab69uH91_tP9cOXj5_v7x5q2_Yi1xZgmoZJ9XLoJUjZcSv5dmxpZzrGQUxGccWFVdvetgqkYLSjwrBSGwYwVNxU7866y7qdYbRl12icXiLOJj7qYFD_3fG417tw1N3Q9oyJIvD2SSCG7yukrGdMFpwzHsKadHGGq3K7oUDbM9TGkFKE6TKGUX3yUx_02c8TS2rGdfGz0N78ueKF9Mu932-A8lFHhKiTRfAWRiymZD0G_P-En4fDuIs</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Gu, Yang</creator><creator>Thompson, Donna</creator><creator>Xu, Jie</creator><creator>Lewis, David F.</creator><creator>Morgan, John A.</creator><creator>Cooper, Danielle B.</creator><creator>McCathran, Charles E.</creator><creator>Wang, Yuping</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8676-7549</orcidid></search><sort><creationdate>20180101</creationdate><title>Aberrant pro-atrial natriuretic peptide/corin/natriuretic peptide receptor signaling is present in maternal vascular endothelium in preeclampsia</title><author>Gu, Yang ; Thompson, Donna ; Xu, Jie ; Lewis, David F. ; Morgan, John A. ; Cooper, Danielle B. ; McCathran, Charles E. ; Wang, Yuping</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c463t-ceeff8f967867e7752c72bd405a512e3fa92923c9b6c49e7310503a192388ea03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>ANP</topic><topic>Atrial Natriuretic Factor - blood</topic><topic>Corin</topic><topic>Endothelium, Vascular - chemistry</topic><topic>Endothelium, Vascular - physiopathology</topic><topic>Female</topic><topic>Humans</topic><topic>NPR</topic><topic>Pre-Eclampsia - blood</topic><topic>Pre-Eclampsia - diagnosis</topic><topic>Pre-Eclampsia - physiopathology</topic><topic>Preeclampsia</topic><topic>Pregnancy</topic><topic>Receptors, Atrial Natriuretic Factor - analysis</topic><topic>Serine Endopeptidases - blood</topic><topic>Signal Transduction</topic><topic>Young Adult</topic><toplevel>online_resources</toplevel><creatorcontrib>Gu, Yang</creatorcontrib><creatorcontrib>Thompson, Donna</creatorcontrib><creatorcontrib>Xu, Jie</creatorcontrib><creatorcontrib>Lewis, David F.</creatorcontrib><creatorcontrib>Morgan, John A.</creatorcontrib><creatorcontrib>Cooper, Danielle B.</creatorcontrib><creatorcontrib>McCathran, Charles E.</creatorcontrib><creatorcontrib>Wang, Yuping</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pregnancy hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gu, Yang</au><au>Thompson, Donna</au><au>Xu, Jie</au><au>Lewis, David F.</au><au>Morgan, John A.</au><au>Cooper, Danielle B.</au><au>McCathran, Charles E.</au><au>Wang, Yuping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aberrant pro-atrial natriuretic peptide/corin/natriuretic peptide receptor signaling is present in maternal vascular endothelium in preeclampsia</atitle><jtitle>Pregnancy hypertension</jtitle><addtitle>Pregnancy Hypertens</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>11</volume><spage>1</spage><epage>6</epage><pages>1-6</pages><issn>2210-7789</issn><eissn>2210-7797</eissn><abstract>•Maternal levels of pro-ANP and its converting enzyme corin are elevated in PE.•Upregulation of NPR-C expression suggests increased ANP clearance/degradation in PE.•Aberrant pro-ANP/corin/NPR signaling may contribute to vascular dysfunction in PE. Corin is a serine protease that converts pro-atrial natriuretic peptide (pro-ANP) to atrial natriuretic peptide (ANP), a cardiac hormone that regulates salt-water balance and blood pressure. ANP is degraded by natriuretic peptide receptor (NPR). This study was to determine if aberrant pro-ANP/corin/NPR signaling is present in maternal vascular system in preeclampsia. Maternal venous blood was obtained from 197 pregnant women (84 normotensive, 16 complicated with chronic hypertension (CHT), 11 mild and 86 severe preeclampsia). Plasma corin and pro-ANP concentrations were measured by enzyme-linked immunosorbent assay. Maternal subcutaneous fat tissue was obtained from 12 pregnant women with cesarean section delivery (6 normotensive and 6 preeclampsia). Vascular ANP and its receptors NPR-A, NPR-B, and NPR-C expression were examined by immunostaining of paraffin embedded subcutaneous fat tissue sections. Corin concentrations were significantly higher in mild (2.78 ± 0.67 ng/ml, p &lt; .05) and severe (2.53 ± 0.18 ng/ml, p &lt; .01) preeclampsia than in normotensive (1.58 ± 0.08 ng/ml) and CHT (1.55 ± 0.20 ng/ml) groups. Pro-ANP concentrations were significantly higher in CHT (1.59 ± 0.53 ng/ml, p &lt; .05) and severe preeclampsia (1.42 ± 0.24 ng/ml, p &lt; .01) than in normotensive (0.48 ± 0.06 ng/ml) and mild preeclampsia (0.52 ± 0.09 ng/ml) groups. ANP and NPR-B expression was undetectable in maternal vessels from normotensive and preeclamptic pregnancies, but reduced NPR-A expression and increased NPR-C expression was found in maternal vessel endothelium in preeclampsia. ANP is a vasodilator and NPR-C is a clearance receptor for ANP. The finding of upregulation of NPR-C expression suggests that circulating ANP clearance or degradation is increased in preeclampsia. These results also suggest that pro-ANP/corin/NPR signaling is dominant in the vascular system in preeclampsia.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>29523263</pmid><doi>10.1016/j.preghy.2017.12.001</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-8676-7549</orcidid><oa>free_for_read</oa></addata></record>
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source Elsevier:Jisc Collections:Elsevier Read and Publish Agreement 2022-2024:Freedom Collection (Reading list)
subjects Adolescent
Adult
ANP
Atrial Natriuretic Factor - blood
Corin
Endothelium, Vascular - chemistry
Endothelium, Vascular - physiopathology
Female
Humans
NPR
Pre-Eclampsia - blood
Pre-Eclampsia - diagnosis
Pre-Eclampsia - physiopathology
Preeclampsia
Pregnancy
Receptors, Atrial Natriuretic Factor - analysis
Serine Endopeptidases - blood
Signal Transduction
Young Adult
title Aberrant pro-atrial natriuretic peptide/corin/natriuretic peptide receptor signaling is present in maternal vascular endothelium in preeclampsia
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