Activity-based sensing fluorescent probes for iron in biological systems

Iron is an essential nutrient for life, and its capacity to cycle between different oxidation states is required for processes spanning oxygen transport and respiration to nucleotide synthesis and epigenetic regulation. However, this same redox ability also makes iron, if not regulated properly, a p...

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Bibliographic Details
Published in:Current opinion in chemical biology 2018-04, Vol.43, p.113-118
Main Authors: Aron, Allegra T, Reeves, Audrey G, Chang, Christopher J
Format: Article
Language:English
Subjects:
Biomimetics
Epigenesis, Genetic
Ferrous Compounds - analysis
Ferrous Compounds - metabolism
Fluorescent Dyes - chemistry
Humans
Iron-Binding Proteins - analysis
Iron-Binding Proteins - metabolism
Oxidation-Reduction
Oxidative Stress
Oxides - metabolism
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Summary:Iron is an essential nutrient for life, and its capacity to cycle between different oxidation states is required for processes spanning oxygen transport and respiration to nucleotide synthesis and epigenetic regulation. However, this same redox ability also makes iron, if not regulated properly, a potentially dangerous toxin that can trigger oxidative stress and damage. New methods that enable monitoring of iron in living biological systems, particularly in labile Fe2+ forms, can help identify its contributions to physiology, aging, and disease. In this review, we summarize recent developments in activity-based sensing (ABS) probes for fluorescence Fe2+ detection.
ISSN:1367-5931
1879-0402
DOI:10.1016/j.cbpa.2017.12.010