Relationship Between Physical Activity, Body Mass Index, and Risk of Heart Failure

• Published in: Journal of the American College of Cardiology 2017-03, Vol.69 (9), p.1129-1142
• Main Authors: Pandey, Ambarish, MD, LaMonte, Michael, PhD, MPH, Klein, Liviu, MD, MS, Ayers, Colby, MS, Psaty, Bruce M., MD, PhD, Eaton, Charles B., MD, MS, Allen, Norrina B., PhD, de Lemos, James A., MD, Carnethon, Mercedes, PhD, Greenland, Philip, MD, Berry, Jarett D., MD, MS
• Format: Article
• Language: English
• Subjects: Age; Aged; Atherosclerosis; Body Mass Index; Cardiology; Cardiovascular; Cohort Studies; Diabetes; Disease prevention; dose–response relationship; Education; Ethnicity; Exercise; Female; Health risk assessment; Heart attacks; Heart failure; Heart Failure - epidemiology; Humans; Hypertension; Internal Medicine; Male; Middle Aged; Obesity; Older people; physical activity; Proportional Hazards Models; Risk Factors; Stroke Volume; Studies; Womens health
• ISSN: 0735-1097; 1558-3597; 1558-3597
• DOI: 10.1016/j.jacc.2016.11.081

Abstract Background Lower leisure-time physical activity (LTPA) and higher body mass index (BMI) are independently associated with risk of heart failure (HF). However, it is unclear if this relationship is consistent for both heart failure with preserved ejection fraction (HFpEF) and heart failure with reduced ejection fraction (HFrEF). Objectives This study sought to quantify dose–response associations between LTPA, BMI, and the risk of different HF subtypes. Methods Individual-level data from 3 cohort studies (WHI [Women’s Health Initiative], MESA [Multi-Ethnic Study of Atherosclerosis], and CHS [Cardiovascular Health Study]) were pooled and participants were stratified into guideline-recommended categories of LTPA and BMI. Associations between LTPA, BMI, and risk of overall HF, HFpEF (ejection fraction ≥45%), and HFrEF (ejection fraction