Cystic Fibrosis Pulmonary Exacerbations Attributable to Respiratory Syncytial Virus and Influenza: A Population-Based Study

Background. Characterization of the role of respiratory viral pathogens on cystic fibrosis (CF) pulmonary disease is needed. We aimed to determine the association of influenza and respiratory syncytial virus (RSV) activity with risk of pulmonary exacerbation (PEx) in persons with CF in the United St...

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Bibliographic Details
Published in:Clinical infectious diseases 2017-06, Vol.64 (12), p.1760-1767
Main Authors: Somayaji, Ranjani, Goss, Christopher H., Khan, Umer, Neradilek, Moni, Neuzil, Kathleen M., Ortiz, Justin R.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Distribution
ARTICLES AND COMMENTARIES
Child
Child, Preschool
Cohort Studies
Cystic Fibrosis - complications
Cystic Fibrosis - physiopathology
Cystic Fibrosis - virology
Disease Progression
Epidemiological Monitoring
Female
Hospitalization
Humans
Incidence
Influenza, Human - complications
Lung - physiopathology
Lung - virology
Major
Male
Middle Aged
Multivariate Analysis
Registries
Respiratory Syncytial Virus Infections - complications
Risk Factors
Young Adult
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Summary:Background. Characterization of the role of respiratory viral pathogens on cystic fibrosis (CF) pulmonary disease is needed. We aimed to determine the association of influenza and respiratory syncytial virus (RSV) activity with risk of pulmonary exacerbation (PEx) in persons with CF in the United States. Methods. We conducted a cohort study from January 2003 to March 2009 using the CF Foundation Patient Registry merged with Centers for Disease Control and Prevention respiratory virus surveillance data. The primary goal was to determine the association between regional influenza or RSV detections with risk of PEx requiring intravenous antibiotics or hospitalization. We analyzed outcomes by geographic region and week of event using multivariable regression models adjusted for demographic and clinical predictors of PEx stratified for children (
ISSN:1058-4838
1537-6591
1537-6591
DOI:10.1093/cid/cix203