Microarchitecture of the Augmented Bone Following Sinus Elevation with an Albumin Impregnated Demineralized Freeze-Dried Bone Allograft (BoneAlbumin) versus Anorganic Bovine Bone Mineral: A Randomized Prospective Clinical, Histomorphometric, and Micro-Computed Tomography Study

Serum albumin has been identified as an endogenous protein that is integral to early bone regeneration. We hypothesized that albumin addition to allografts may result in better bone remodeling than what can be achieved with anorganic xenografts. Sinus elevations were performed at 32 sites of 18 pati...

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Published in:Materials 2018-01, Vol.11 (2), p.202
Main Authors: Márton, Kivovics, Tamás, Szabó Bence, Orsolya, Németh, Béla, Czinkóczky, Ferenc, Dőri, Péter, Nagy, Csaba, Dobó-Nagy, Lajos, Csönge, Zsombor, Lacza, Eitan, Mijiritsky, György, Szabó
Format: Article
Language:English
Subjects:
Biopsy
Computed tomography
Computer architecture
Demineralizing
Dental implants
Local anesthesia
Medical research
Metabolism
Patients
Regeneration (physiology)
Serum albumin
Sinuses
Skin & tissue grafts
Stem cells
Surgery
Surgical implants
Sutures
Transplants & implants
Xenotransplantation
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Summary:Serum albumin has been identified as an endogenous protein that is integral to early bone regeneration. We hypothesized that albumin addition to allografts may result in better bone remodeling than what can be achieved with anorganic xenografts. Sinus elevations were performed at 32 sites of 18 patients with the lateral window technique. Sites either received filling with an anorganic bovine bone mineral (ABBM, BioOss, Geistlich, CH) or albumin impregnated allograft (BoneAlbumin, OrthoSera, AT). After 6-months patients received dental implants and 16 bone core biopsy samples were obtained from the ABBM filled, and 16 from the BoneAlbumin augmented sites. The biopsies were examined by histomorphometry and µCT. Percentage of the residual graft in the BoneAlbumin group was 0-12.7%, median 5.4% vs. ABBM 6.3-35.9%, median 16.9%, < 0.05. Results of the µCT analysis showed that the microarchitecture of the augmented bone in the BoneAlbumin group resembles that of the native maxilla in morphometric parameters Trabecular Pattern Factor and Connectivity. Our data show that while ABBM successfully integrates into the newly formed bone tissue as persisting particles, BoneAlbumin is underway towards complete remodeling with new bone closely resembling that of the intact maxilla.
ISSN:1996-1944
1996-1944
DOI:10.3390/ma11020202