Carbon-Fibre-Reinforced SiC Composite (C/SiSiC) as an Alternative Material for Endoprosthesis: Fabrication, Mechanical and In-Vitro Biological Properties

Particle-induced periprosthetic osteolysis and subsequent aseptic implant loosening are a major cause of compromising the long-term results of total joint replacements. To date, no implant has been able to mirror radically the tribological factors (friction/lubrication/wear) of in vivo tribological...

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Bibliographic Details
Published in:Materials 2018-02, Vol.11 (2), p.316
Main Authors: Reichert, Aline, Seidenstuecker, Michael, Gadow, Rainer, Mayr, Hermann O, Suedkamp, Norbert P, Latorre, Sergio H, Weichand, Partick, Bernstein, Anke
Format: Article
Language:English
Subjects:
Biocompatibility
Biological properties
Carbon-silicon carbide composites
Ceramics
Coefficient of friction
Cytotoxicity
Fiber composites
Flexural strength
High resistance
In vivo methods and tests
Microscopy
Modulus of elasticity
Morphology
Optical microscopy
Orthopedics
Toxicity
Tribology
Wear resistance
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Summary:Particle-induced periprosthetic osteolysis and subsequent aseptic implant loosening are a major cause of compromising the long-term results of total joint replacements. To date, no implant has been able to mirror radically the tribological factors (friction/lubrication/wear) of in vivo tribological pairings. Carbon-Fibre Reinforced SiC-Composites (C/SiSiC), a material primarily developed for brake technology, has the opportunity to fulfil this requirement. Until now, the material itself has not been used in medicine. The aim of this investigation was to test the suitability of C/SiSiC ceramics as a new material for bearing couples in endoprosthetics. After the preparation of the composites flexural strength was determined as well as the Young's-modulus and the coefficient of friction. To investigate in vitro biological properties, MG 63 and primary human osteoblasts were cultured on C/SiSiC composites. To review the proliferation, the cytotoxicity standardized tests were used. The cell morphology was observed by light microscopy, ESEM, confocal and 3D-laserscanning microscopy. C/SiSiC possesses a high resistance to wear. Cells exhibited no significant alterations in morphology. Vitality was not impaired by contact with the ceramic composite. There was no higher cytotoxicity to observe. Regarding these results, C/SiSiC ceramics seem to be biologically and mechanically appropriate for orthopaedic applications.
ISSN:1996-1944
1996-1944
DOI:10.3390/ma11020316