Loading…
Partner Bereavement and Risk of Herpes Zoster: Results from Two Population-Based Case-Control Studies in Denmark and the United Kingdom
Background. Psychological stress is commonly thought to increase the risk of herpes zoster by causing immunosuppression. However, epidemiological studies on the topic are sparse and inconsistent. We conducted 2 parallel case-control studies of the association between partner bereavement and risk of...
Saved in:
Published in: | Clinical infectious diseases 2017-03, Vol.64 (5), p.572-579 |
---|---|
Main Authors: | , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | cdi_FETCH-LOGICAL-c461t-38b71ea92e8846623d943720eb556e93d9da5f5a87b3f34b87d3f60c21e7be153 |
---|---|
cites | cdi_FETCH-LOGICAL-c461t-38b71ea92e8846623d943720eb556e93d9da5f5a87b3f34b87d3f60c21e7be153 |
container_end_page | 579 |
container_issue | 5 |
container_start_page | 572 |
container_title | Clinical infectious diseases |
container_volume | 64 |
creator | Schmidt, Sigrun A. J. Vestergaard, Mogens Pedersen, Henrik S. Schønheyder, Henrik C. Thomas, Sara L. Smeeth, Liam Mansfield, Kathryn E. Sørensen, Henrik T. Forbes, Harriet J. Langan, Sinéad M. |
description | Background. Psychological stress is commonly thought to increase the risk of herpes zoster by causing immunosuppression. However, epidemiological studies on the topic are sparse and inconsistent. We conducted 2 parallel case-control studies of the association between partner bereavement and risk of zoster using electronic healthcare data covering the entire Danish population and general practices in the UK Clinical Practice Research Datalink. Methods. We included patients with a zoster diagnosis from the primary care or hospital-based setting in 1997–2013 in Denmark (n = 190 671) and 2000–2013 in the United Kingdom (n = 150 207). We matched up to 4 controls to each case patient by age, sex, and general practice (United Kingdom only) using risk-set sampling. The date of diagnosis was the index date for case patients and their controls. We computed adjusted odds ratios with 99% confidence intervals for previous bereavement among case patients versus controls using conditional logistic regression with results from the 2 settings pooled using random-effects meta-analysis. Results. Overall, the adjusted odds ratios for the association between partner bereavement and zoster were 1.05 (99% confidence interval, 1.03–1.07) in Denmark and 1.01 (.98–1.05) in the United Kingdom. The pooled estimates were 0.72, 0.90, 1.10, 1.08, 1.02, 1.04, and 1.03 for bereavement within 0–7, 8–14, 15–30, 31–90, 91–365, 366–1095, and >1095 days before the index date, respectively. Conclusions. We found no consistent evidence of an increased risk of zoster after partner death. Initial fluctuations in estimates may be explained by delayed healthcare contact due to the loss. |
doi_str_mv | 10.1093/cid/ciw840 |
format | article |
fullrecord | <record><control><sourceid>jstor_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5850543</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>26373769</jstor_id><sourcerecordid>26373769</sourcerecordid><originalsourceid>FETCH-LOGICAL-c461t-38b71ea92e8846623d943720eb556e93d9da5f5a87b3f34b87d3f60c21e7be153</originalsourceid><addsrcrecordid>eNqNkk1PFTEUhidGIohu3GuasDEmg_1ux4WJXBWMJBKEjZumM3MGeplpL20H4i_wb1u4iB8rF_3Kec6bc07fqnpG8C7BDXvdub6sa83xg2qLCKZqKRrysNyx0DXXTG9Wj1NaYkyIxuJRtUlVo6XUYqv6cWRj9hDRHkSwVzCBz8j6Hh27dIHCgA4griChbyFliG_QMaR5zAkNMUzo5Dqgo7CaR5td8PWeTdCjRdnrRfA5hhF9zXPvSrrz6D34ycaLW_F8DujUu1zwz86f9WF6Um0Mdkzw9O7crk4_fjhZHNSHX_Y_Ld4d1h2XJNdMt4qAbShozaWkrG84UxRDK4SEpjx7KwZhtWrZwHirVc8GiTtKQLVQZrNdvV3rruZ2gr4r7UY7mlV0pbjvJlhn_o54d27OwpURWmDBWRF4eScQw-UMKZvJpQ7G0XoIczJEK6U5YUL-ByqobIjWqqA7_6DLMEdfJnEjSAlVnOpCvVpTXQwpRRju6ybY3FjBFCuYtRUK_OLPTu_RX39fgOdrYJlyiL_jkimmZMN-At5fuqo</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1872127428</pqid></control><display><type>article</type><title>Partner Bereavement and Risk of Herpes Zoster: Results from Two Population-Based Case-Control Studies in Denmark and the United Kingdom</title><source>JSTOR Archival Journals and Primary Sources Collection</source><source>Oxford Journals Online</source><creator>Schmidt, Sigrun A. J. ; Vestergaard, Mogens ; Pedersen, Henrik S. ; Schønheyder, Henrik C. ; Thomas, Sara L. ; Smeeth, Liam ; Mansfield, Kathryn E. ; Sørensen, Henrik T. ; Forbes, Harriet J. ; Langan, Sinéad M.</creator><creatorcontrib>Schmidt, Sigrun A. J. ; Vestergaard, Mogens ; Pedersen, Henrik S. ; Schønheyder, Henrik C. ; Thomas, Sara L. ; Smeeth, Liam ; Mansfield, Kathryn E. ; Sørensen, Henrik T. ; Forbes, Harriet J. ; Langan, Sinéad M.</creatorcontrib><description>Background. Psychological stress is commonly thought to increase the risk of herpes zoster by causing immunosuppression. However, epidemiological studies on the topic are sparse and inconsistent. We conducted 2 parallel case-control studies of the association between partner bereavement and risk of zoster using electronic healthcare data covering the entire Danish population and general practices in the UK Clinical Practice Research Datalink. Methods. We included patients with a zoster diagnosis from the primary care or hospital-based setting in 1997–2013 in Denmark (n = 190 671) and 2000–2013 in the United Kingdom (n = 150 207). We matched up to 4 controls to each case patient by age, sex, and general practice (United Kingdom only) using risk-set sampling. The date of diagnosis was the index date for case patients and their controls. We computed adjusted odds ratios with 99% confidence intervals for previous bereavement among case patients versus controls using conditional logistic regression with results from the 2 settings pooled using random-effects meta-analysis. Results. Overall, the adjusted odds ratios for the association between partner bereavement and zoster were 1.05 (99% confidence interval, 1.03–1.07) in Denmark and 1.01 (.98–1.05) in the United Kingdom. The pooled estimates were 0.72, 0.90, 1.10, 1.08, 1.02, 1.04, and 1.03 for bereavement within 0–7, 8–14, 15–30, 31–90, 91–365, 366–1095, and >1095 days before the index date, respectively. Conclusions. We found no consistent evidence of an increased risk of zoster after partner death. Initial fluctuations in estimates may be explained by delayed healthcare contact due to the loss.</description><identifier>ISSN: 1058-4838</identifier><identifier>ISSN: 1537-6591</identifier><identifier>EISSN: 1537-6591</identifier><identifier>DOI: 10.1093/cid/ciw840</identifier><identifier>PMID: 27986685</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Adult ; Aged ; Aged, 80 and over ; ARTICLES AND COMMENTARIES ; Bereavement ; Case-Control Studies ; Denmark - epidemiology ; Epidemiology ; Female ; Grief ; Herpes viruses ; Herpes Zoster - epidemiology ; Herpes Zoster - etiology ; Humans ; Major ; Male ; Middle Aged ; Odds Ratio ; Population Surveillance ; Risk ; Risk factors ; Sampling ; Socioeconomic Factors ; Stress, Psychological ; Time Factors ; United Kingdom - epidemiology</subject><ispartof>Clinical infectious diseases, 2017-03, Vol.64 (5), p.572-579</ispartof><rights>Copyright © 2017 Oxford University Press on behalf of the Infectious Diseases Society of America</rights><rights>The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America.</rights><rights>Copyright Oxford University Press, UK Mar 1, 2017</rights><rights>The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c461t-38b71ea92e8846623d943720eb556e93d9da5f5a87b3f34b87d3f60c21e7be153</citedby><cites>FETCH-LOGICAL-c461t-38b71ea92e8846623d943720eb556e93d9da5f5a87b3f34b87d3f60c21e7be153</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/26373769$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/26373769$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,58238,58471</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27986685$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schmidt, Sigrun A. J.</creatorcontrib><creatorcontrib>Vestergaard, Mogens</creatorcontrib><creatorcontrib>Pedersen, Henrik S.</creatorcontrib><creatorcontrib>Schønheyder, Henrik C.</creatorcontrib><creatorcontrib>Thomas, Sara L.</creatorcontrib><creatorcontrib>Smeeth, Liam</creatorcontrib><creatorcontrib>Mansfield, Kathryn E.</creatorcontrib><creatorcontrib>Sørensen, Henrik T.</creatorcontrib><creatorcontrib>Forbes, Harriet J.</creatorcontrib><creatorcontrib>Langan, Sinéad M.</creatorcontrib><title>Partner Bereavement and Risk of Herpes Zoster: Results from Two Population-Based Case-Control Studies in Denmark and the United Kingdom</title><title>Clinical infectious diseases</title><addtitle>Clin Infect Dis</addtitle><description>Background. Psychological stress is commonly thought to increase the risk of herpes zoster by causing immunosuppression. However, epidemiological studies on the topic are sparse and inconsistent. We conducted 2 parallel case-control studies of the association between partner bereavement and risk of zoster using electronic healthcare data covering the entire Danish population and general practices in the UK Clinical Practice Research Datalink. Methods. We included patients with a zoster diagnosis from the primary care or hospital-based setting in 1997–2013 in Denmark (n = 190 671) and 2000–2013 in the United Kingdom (n = 150 207). We matched up to 4 controls to each case patient by age, sex, and general practice (United Kingdom only) using risk-set sampling. The date of diagnosis was the index date for case patients and their controls. We computed adjusted odds ratios with 99% confidence intervals for previous bereavement among case patients versus controls using conditional logistic regression with results from the 2 settings pooled using random-effects meta-analysis. Results. Overall, the adjusted odds ratios for the association between partner bereavement and zoster were 1.05 (99% confidence interval, 1.03–1.07) in Denmark and 1.01 (.98–1.05) in the United Kingdom. The pooled estimates were 0.72, 0.90, 1.10, 1.08, 1.02, 1.04, and 1.03 for bereavement within 0–7, 8–14, 15–30, 31–90, 91–365, 366–1095, and >1095 days before the index date, respectively. Conclusions. We found no consistent evidence of an increased risk of zoster after partner death. Initial fluctuations in estimates may be explained by delayed healthcare contact due to the loss.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>ARTICLES AND COMMENTARIES</subject><subject>Bereavement</subject><subject>Case-Control Studies</subject><subject>Denmark - epidemiology</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Grief</subject><subject>Herpes viruses</subject><subject>Herpes Zoster - epidemiology</subject><subject>Herpes Zoster - etiology</subject><subject>Humans</subject><subject>Major</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Odds Ratio</subject><subject>Population Surveillance</subject><subject>Risk</subject><subject>Risk factors</subject><subject>Sampling</subject><subject>Socioeconomic Factors</subject><subject>Stress, Psychological</subject><subject>Time Factors</subject><subject>United Kingdom - epidemiology</subject><issn>1058-4838</issn><issn>1537-6591</issn><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNqNkk1PFTEUhidGIohu3GuasDEmg_1ux4WJXBWMJBKEjZumM3MGeplpL20H4i_wb1u4iB8rF_3Kec6bc07fqnpG8C7BDXvdub6sa83xg2qLCKZqKRrysNyx0DXXTG9Wj1NaYkyIxuJRtUlVo6XUYqv6cWRj9hDRHkSwVzCBz8j6Hh27dIHCgA4griChbyFliG_QMaR5zAkNMUzo5Dqgo7CaR5td8PWeTdCjRdnrRfA5hhF9zXPvSrrz6D34ycaLW_F8DujUu1zwz86f9WF6Um0Mdkzw9O7crk4_fjhZHNSHX_Y_Ld4d1h2XJNdMt4qAbShozaWkrG84UxRDK4SEpjx7KwZhtWrZwHirVc8GiTtKQLVQZrNdvV3rruZ2gr4r7UY7mlV0pbjvJlhn_o54d27OwpURWmDBWRF4eScQw-UMKZvJpQ7G0XoIczJEK6U5YUL-ByqobIjWqqA7_6DLMEdfJnEjSAlVnOpCvVpTXQwpRRju6ybY3FjBFCuYtRUK_OLPTu_RX39fgOdrYJlyiL_jkimmZMN-At5fuqo</recordid><startdate>20170301</startdate><enddate>20170301</enddate><creator>Schmidt, Sigrun A. J.</creator><creator>Vestergaard, Mogens</creator><creator>Pedersen, Henrik S.</creator><creator>Schønheyder, Henrik C.</creator><creator>Thomas, Sara L.</creator><creator>Smeeth, Liam</creator><creator>Mansfield, Kathryn E.</creator><creator>Sørensen, Henrik T.</creator><creator>Forbes, Harriet J.</creator><creator>Langan, Sinéad M.</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T2</scope><scope>7T7</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><scope>7U2</scope><scope>5PM</scope></search><sort><creationdate>20170301</creationdate><title>Partner Bereavement and Risk of Herpes Zoster: Results from Two Population-Based Case-Control Studies in Denmark and the United Kingdom</title><author>Schmidt, Sigrun A. J. ; Vestergaard, Mogens ; Pedersen, Henrik S. ; Schønheyder, Henrik C. ; Thomas, Sara L. ; Smeeth, Liam ; Mansfield, Kathryn E. ; Sørensen, Henrik T. ; Forbes, Harriet J. ; Langan, Sinéad M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c461t-38b71ea92e8846623d943720eb556e93d9da5f5a87b3f34b87d3f60c21e7be153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>ARTICLES AND COMMENTARIES</topic><topic>Bereavement</topic><topic>Case-Control Studies</topic><topic>Denmark - epidemiology</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Grief</topic><topic>Herpes viruses</topic><topic>Herpes Zoster - epidemiology</topic><topic>Herpes Zoster - etiology</topic><topic>Humans</topic><topic>Major</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Odds Ratio</topic><topic>Population Surveillance</topic><topic>Risk</topic><topic>Risk factors</topic><topic>Sampling</topic><topic>Socioeconomic Factors</topic><topic>Stress, Psychological</topic><topic>Time Factors</topic><topic>United Kingdom - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schmidt, Sigrun A. J.</creatorcontrib><creatorcontrib>Vestergaard, Mogens</creatorcontrib><creatorcontrib>Pedersen, Henrik S.</creatorcontrib><creatorcontrib>Schønheyder, Henrik C.</creatorcontrib><creatorcontrib>Thomas, Sara L.</creatorcontrib><creatorcontrib>Smeeth, Liam</creatorcontrib><creatorcontrib>Mansfield, Kathryn E.</creatorcontrib><creatorcontrib>Sørensen, Henrik T.</creatorcontrib><creatorcontrib>Forbes, Harriet J.</creatorcontrib><creatorcontrib>Langan, Sinéad M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Safety Science and Risk</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schmidt, Sigrun A. J.</au><au>Vestergaard, Mogens</au><au>Pedersen, Henrik S.</au><au>Schønheyder, Henrik C.</au><au>Thomas, Sara L.</au><au>Smeeth, Liam</au><au>Mansfield, Kathryn E.</au><au>Sørensen, Henrik T.</au><au>Forbes, Harriet J.</au><au>Langan, Sinéad M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Partner Bereavement and Risk of Herpes Zoster: Results from Two Population-Based Case-Control Studies in Denmark and the United Kingdom</atitle><jtitle>Clinical infectious diseases</jtitle><addtitle>Clin Infect Dis</addtitle><date>2017-03-01</date><risdate>2017</risdate><volume>64</volume><issue>5</issue><spage>572</spage><epage>579</epage><pages>572-579</pages><issn>1058-4838</issn><issn>1537-6591</issn><eissn>1537-6591</eissn><abstract>Background. Psychological stress is commonly thought to increase the risk of herpes zoster by causing immunosuppression. However, epidemiological studies on the topic are sparse and inconsistent. We conducted 2 parallel case-control studies of the association between partner bereavement and risk of zoster using electronic healthcare data covering the entire Danish population and general practices in the UK Clinical Practice Research Datalink. Methods. We included patients with a zoster diagnosis from the primary care or hospital-based setting in 1997–2013 in Denmark (n = 190 671) and 2000–2013 in the United Kingdom (n = 150 207). We matched up to 4 controls to each case patient by age, sex, and general practice (United Kingdom only) using risk-set sampling. The date of diagnosis was the index date for case patients and their controls. We computed adjusted odds ratios with 99% confidence intervals for previous bereavement among case patients versus controls using conditional logistic regression with results from the 2 settings pooled using random-effects meta-analysis. Results. Overall, the adjusted odds ratios for the association between partner bereavement and zoster were 1.05 (99% confidence interval, 1.03–1.07) in Denmark and 1.01 (.98–1.05) in the United Kingdom. The pooled estimates were 0.72, 0.90, 1.10, 1.08, 1.02, 1.04, and 1.03 for bereavement within 0–7, 8–14, 15–30, 31–90, 91–365, 366–1095, and >1095 days before the index date, respectively. Conclusions. We found no consistent evidence of an increased risk of zoster after partner death. Initial fluctuations in estimates may be explained by delayed healthcare contact due to the loss.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>27986685</pmid><doi>10.1093/cid/ciw840</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1058-4838 |
ispartof | Clinical infectious diseases, 2017-03, Vol.64 (5), p.572-579 |
issn | 1058-4838 1537-6591 1537-6591 |
language | eng |
recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5850543 |
source | JSTOR Archival Journals and Primary Sources Collection; Oxford Journals Online |
subjects | Adult Aged Aged, 80 and over ARTICLES AND COMMENTARIES Bereavement Case-Control Studies Denmark - epidemiology Epidemiology Female Grief Herpes viruses Herpes Zoster - epidemiology Herpes Zoster - etiology Humans Major Male Middle Aged Odds Ratio Population Surveillance Risk Risk factors Sampling Socioeconomic Factors Stress, Psychological Time Factors United Kingdom - epidemiology |
title | Partner Bereavement and Risk of Herpes Zoster: Results from Two Population-Based Case-Control Studies in Denmark and the United Kingdom |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T14%3A21%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Partner%20Bereavement%20and%20Risk%20of%20Herpes%20Zoster:%20Results%20from%20Two%20Population-Based%20Case-Control%20Studies%20in%20Denmark%20and%20the%20United%20Kingdom&rft.jtitle=Clinical%20infectious%20diseases&rft.au=Schmidt,%20Sigrun%20A.%20J.&rft.date=2017-03-01&rft.volume=64&rft.issue=5&rft.spage=572&rft.epage=579&rft.pages=572-579&rft.issn=1058-4838&rft.eissn=1537-6591&rft_id=info:doi/10.1093/cid/ciw840&rft_dat=%3Cjstor_pubme%3E26373769%3C/jstor_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c461t-38b71ea92e8846623d943720eb556e93d9da5f5a87b3f34b87d3f60c21e7be153%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1872127428&rft_id=info:pmid/27986685&rft_jstor_id=26373769&rfr_iscdi=true |