Manipulation of host and parasite microbiotas: Survival strategies during chronic nematode infection

Intestinal dwelling parasites have evolved closely with the complex intestinal microbiota of their host, but the significance of the host microbiota for metazoan pathogens and the role of their own intestinal microbiota are still not fully known. We have found that the parasitic nematode acquired a...

Full description

Saved in:
Bibliographic Details
Published in:Science advances 2018-03, Vol.4 (3), p.eaap7399
Main Authors: White, Emily C, Houlden, Ashley, Bancroft, Allison J, Hayes, Kelly S, Goldrick, Marie, Grencis, Richard K, Roberts, Ian S
Format: Article
Language:English
Subjects:
Adaptive Immunity - drug effects
Animals
Anti-Bacterial Agents - pharmacology
Host-Parasite Interactions - drug effects
Host-Parasite Interactions - immunology
Intestines - microbiology
Intestines - parasitology
Mice, Inbred C57BL
Microbiology
Microbiota - drug effects
Parasites - drug effects
Parasites - immunology
Parasites - microbiology
SciAdv r-articles
Trichuriasis - immunology
Trichuriasis - microbiology
Trichuris - drug effects
Trichuris - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Intestinal dwelling parasites have evolved closely with the complex intestinal microbiota of their host, but the significance of the host microbiota for metazoan pathogens and the role of their own intestinal microbiota are still not fully known. We have found that the parasitic nematode acquired a distinct intestinal microbiota from its host, which was required for nematode fitness. Infection of germ-free mice and mice monocolonized with demonstrated that successful infections require a host microbiota. Following infection, -induced alterations in the host intestinal microbiota inhibited subsequent rounds of infection, controlling parasite numbers within the host intestine. This dual strategy could promote the long-term survival of the parasite within the intestinal niche necessary for successful chronic nematode infection.
ISSN:2375-2548
2375-2548
DOI:10.1126/sciadv.aap7399