Vitamin D-Binding Protein Polymorphisms, 25-Hydroxyvitamin D, Sunshine and Multiple Sclerosis

Blacks have different dominant polymorphisms in the vitamin D-binding protein (DBP) gene that result in higher bioavailable vitamin D than whites. This study tested whether the lack of association between 25-hydroxyvitamin D (25OHD) and multiple sclerosis (MS) risk in blacks and Hispanics is due to...

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Bibliographic Details
Published in:Nutrients 2018-02, Vol.10 (2), p.184
Main Authors: Langer-Gould, Annette, Lucas, Robyn M, Xiang, Anny H, Wu, Jun, Chen, Lie H, Gonzales, Edlin, Haraszti, Samantha, Smith, Jessica B, Quach, Hong, Barcellos, Lisa F
Format: Article
Language:English
Subjects:
25-Hydroxyvitamin D
Alleles
Bioavailability
Blacks
California
genotype
Genotypes
Hispanic people
Hispanics
Multiple sclerosis
Radiation effects
Risk
sclerosis
solar radiation
Ultraviolet radiation
Vitamin D
Vitamin D-binding protein
Vitamin deficiency
Whites
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Summary:Blacks have different dominant polymorphisms in the vitamin D-binding protein (DBP) gene that result in higher bioavailable vitamin D than whites. This study tested whether the lack of association between 25-hydroxyvitamin D (25OHD) and multiple sclerosis (MS) risk in blacks and Hispanics is due to differences in these common polymorphisms (rs7041, rs4588). We recruited incident MS cases and controls (blacks 116 cases/131 controls; Hispanics 183/197; whites 247/267) from Kaiser Permanente Southern California. AA is the dominant rs7041 genotype in blacks (70.0%) whereas C is the dominant allele in whites (79.0% AC/CC) and Hispanics (77.1%). Higher 25OHD levels were associated with a lower risk of MS in whites who carried at least one copy of the C allele but not AA carriers. No association was found in Hispanics or blacks regardless of genotype. Higher ultraviolet radiation exposure was associated with a lower risk of MS in blacks (OR = 0.06), Hispanics and whites who carried at least one copy of the C allele but not in others. Racial/ethnic variations in bioavailable vitamin D do not explain the lack of association between 25OHD and MS in blacks and Hispanics. These findings further challenge the biological plausibility of vitamin D deficiency as causal for MS.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu10020184