The Role of Phylogenetics as a Tool to Predict the Spread of Resistance

Drug resistance mutations emerge in genetic sequences of HIV through drug-selective pressure. Drug resistance can be transmitted. In this review we discuss phylogenetic methods used to study the emergence of drug resistance and the spread of resistant viruses.

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Bibliographic Details
Published in:The Journal of infectious diseases 2017-12, Vol.216 (suppl_9), p.S820-S823
Main Authors: Zhukova, Anna, Cutino-Moguel, Teresa, Gascuel, Olivier, Pillay, Deenan
Format: Article
Language:English
Subjects:
Anti-HIV Agents - therapeutic use
Bioinformatics
Computer Science
Drug Resistance, Viral - genetics
HIV - drug effects
HIV - genetics
HIV Infections - drug therapy
HIV Infections - epidemiology
HIV Infections - virology
Humans
Mutation - genetics
Phylogeny
Supplement
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Description
Summary:Drug resistance mutations emerge in genetic sequences of HIV through drug-selective pressure. Drug resistance can be transmitted. In this review we discuss phylogenetic methods used to study the emergence of drug resistance and the spread of resistant viruses.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/jix411