Rapid Protective Effects of Early BCG on Neonatal Mortality Among Low Birth Weight Boys: Observations From Randomized Trials

BCG vaccination nonspecifically reduces mortality in infants. Using data from three randomized trials, we find that BCG at birth reduces mortality in boys already within the first week of immunization, whereas girls experience the largest effect 2–4 weeks after immunization. Abstract Background Thre...

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Bibliographic Details
Published in:The Journal of infectious diseases 2018-02, Vol.217 (5), p.759-766
Main Authors: Biering-Sørensen, Sofie, Jensen, Kristoffer Jarlov, Monterio, Ivan, Ravn, Henrik, Aaby, Peter, Benn, Christine Stabell
Format: Article
Language:English
Subjects:
Age Factors
BCG Vaccine - administration & dosage
Female
Humans
Infant
Infant Mortality
Infant, Low Birth Weight
Infant, Newborn
Major and Brief Reports
Male
Randomized Controlled Trials as Topic
Sex Factors
Treatment Outcome
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Summary:BCG vaccination nonspecifically reduces mortality in infants. Using data from three randomized trials, we find that BCG at birth reduces mortality in boys already within the first week of immunization, whereas girls experience the largest effect 2–4 weeks after immunization. Abstract Background Three randomized trials (RCTs) in low-weight (
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/jix612