Roles of flotillins in tumors

The identification and use of molecular biomarkers have greatly improved the diagnosis and treatment of malignant tumors. However, a much deeper understanding of oncogenic proteins is needed for the benefit to cancer patients. The lipid raft marker proteins, flotillin-1 and flotillin-2, were first f...

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Published in:Journal of Zhejiang University. B. Science 2018-03, Vol.19 (3), p.171-182
Main Authors: Liu, Xu-xu, Liu, Wei-dong, Wang, Lei, Zhu, Bin, Shi, Xiao, Peng, Zi-xuan, Zhu, He-cheng, Liu, Xing-dong, Zhong, Mei-zuo, Xie, Dan, Zeng, Mu-sheng, Ren, Cai-ping
Format: Article
Language:English
Subjects:
Biomarkers
Biomedical and Life Sciences
Biomedicine
Cancer
Cell activation
Cell membranes
Diagnosis
Endocytosis
Membranes
Metastases
Protein interaction
Proteins
Regeneration
Retina
Retinal ganglion cells
Review
Signal transduction
Tumors
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Summary:The identification and use of molecular biomarkers have greatly improved the diagnosis and treatment of malignant tumors. However, a much deeper understanding of oncogenic proteins is needed for the benefit to cancer patients. The lipid raft marker proteins, flotillin-1 and flotillin-2, were first found in goldfish retinal ganglion cells during axon regeneration. They have since been found in a variety of cells, mainly on the inner surface of cell membranes, and not only act as a skeleton to provide a platform for protein–protein interactions, but also are involved in signal transduction, nerve regeneration, endocytosis, and lymphocyte activation. Previous studies have shown that flotillins are closely associated with tumor development, invasion, and metastasis. In this article, we review the functions of flotillins in relevant cell processes, their underlying mechanisms of action in a variety of tumors, and their potential applications to tumor molecular diagnosis and targeted therapy.
ISSN:1673-1581
1862-1783
DOI:10.1631/jzus.B1700102