Migraine and invasive epithelial ovarian cancer risk in the Nurses’ Health Study II and the Women's Health Study

Migraine is a common primary headache disorder, which predominantly impacts women. Recently, migraine has been hypothesized to be associated with hormonally related cancers; however, the potential association between migraine and ovarian cancer has not been studied. Therefore, we evaluated the assoc...

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Bibliographic Details
Published in:International journal of cancer 2018-02, Vol.142 (3), p.534-539
Main Authors: Rice, Megan S., Rist, Pamela M., Winter, Anke C., Kurth, Tobias, Tworoger, Shelley S.
Format: Article
Language:English
Subjects:
Age
Cancer
Carcinoma, Ovarian Epithelial
Cohort Studies
Estrogens
Female
Headache
Health risk assessment
Health risks
Humans
Invasiveness
Medical personnel
Medical research
Middle Aged
Migraine
Migraine Disorders - epidemiology
Neoplasms, Glandular and Epithelial - epidemiology
Nurses
Nurses - statistics & numerical data
Ovarian cancer
Ovarian carcinoma
Ovarian Neoplasms - epidemiology
Prospective Studies
Risk
Statistical analysis
Statistical models
Surveys and Questionnaires
United States - epidemiology
Women's Health
Womens health
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Summary:Migraine is a common primary headache disorder, which predominantly impacts women. Recently, migraine has been hypothesized to be associated with hormonally related cancers; however, the potential association between migraine and ovarian cancer has not been studied. Therefore, we evaluated the association between migraine and invasive epithelial ovarian cancer risk in two prospective cohorts, the Nurses’ Health Study II (NHSII) and the Women's Health Study (WHS). Our prospective analysis included 113,124 NHSII participants aged 25–42 at study baseline as well as 33,490 participants in the WHS who were 45 years or older at study entry. We used Cox proportional hazards models to estimate the hazard ratios (HR) and 95% confidence intervals (CIs) for the association between migraine and ovarian cancer risk in each cohort. In secondary analyses, we stratified by age and menopausal status. After adjusting for potential covariates, there was no statistically significant association between migraine and ovarian cancer risk in either the NHSII (HR = 1.29, 95%CI: 0.96, 1.74) or the WHS (HR = 0.60, 95%CI: 0.34, 1.06). In stratified analysis in the NHSII, there was a statistically significant positive association between migraine and ovarian cancer risk among women
ISSN:0020-7136
1097-0215
DOI:10.1002/ijc.31062