The impact of vessel size, orientation and intravascular contribution on the neurovascular fingerprint of BOLD bSSFP fMRI

Monte Carlo simulations have been used to analyze oxygenation-related signal changes in pass-band balanced steady state free precession (bSSFP) as well as in gradient echo (GE) and spin echo (SE) sequences. Signal changes were calculated for artificial cylinders and neurovascular networks acquired f...

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Bibliographic Details
Published in:NeuroImage (Orlando, Fla.) Fla.), 2017-12, Vol.163, p.13-23
Main Authors: Báez-Yánez, Mario Gilberto, Ehses, Philipp, Mirkes, Christian, Tsai, Philbert S., Kleinfeld, David, Scheffler, Klaus
Format: Article
Language:English
Subjects:
Animals
Balanced SSFP
Blood
Blood volume
Brain
Brain - blood supply
Brain - diagnostic imaging
Brain Mapping - methods
Computer simulation
Confocal microscopy
Cortex (parietal)
Extra- and intravascular contribution
Functional magnetic resonance imaging
Image Processing, Computer-Assisted
Layer specific BOLD fMRI
Magnetic fields
Magnetic Resonance Imaging - methods
Medical imaging
Mice
Microscopy
Microvasculature
Monte Carlo Method
Noise
Orientation-dependent BOLD fMRI
Oxygen - blood
Oxygenation
Scanning microscopy
Vascular cortical network
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Summary:Monte Carlo simulations have been used to analyze oxygenation-related signal changes in pass-band balanced steady state free precession (bSSFP) as well as in gradient echo (GE) and spin echo (SE) sequences. Signal changes were calculated for artificial cylinders and neurovascular networks acquired from the mouse parietal cortex by two-photon laser scanning microscopy at 1 μm isotropic resolution. Signal changes as a function of vessel size, blood volume, vessel orientation to the main magnetic field B0 as well as relations of intra- and extravascular and of micro- and macrovascular contributions have been analyzed. The results show that bSSFP is highly sensitive to extravascular and microvascular components. Furthermore, GE and bSSFP, and to a lesser extent SE, exhibit a strong dependence of their signal change on the orientation of the vessel network to B0. •The contribution from capillaries is highest for SE, followed by bSSFP and is much lower for GE.•The intravascular contribution of bSSFP and SE is in the range of 5–10%, and negligible for GE at 9.4T.•BOLD signal change of GE, SE and bSSFP depend on orientation of cortex to B0.
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2017.09.015