Urinary Metabolites Associated with Blood Pressure on a Low- or High-Sodium Diet

Dietary salt intake has significant effects on arterial blood pressure and the development of hypertension. Mechanisms underlying salt-dependent changes in blood pressure remain poorly understood, and it is difficult to assess blood pressure salt-sensitivity clinically. We examined urinary levels of...

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Bibliographic Details
Published in:Theranostics 2018-01, Vol.8 (6), p.1468-1480
Main Authors: Cheng, Yuan, Song, Haiying, Pan, Xiaoqing, Xue, Hong, Wan, Yifei, Wang, Tao, Tian, Zhongmin, Hou, Entai, Lanza, Ian R, Liu, Pengyuan, Liu, Yong, Laud, Purushottam W, Usa, Kristie, He, Yongcheng, Liang, Mingyu
Format: Article
Language:English
Subjects:
Adult
Amino Acids - urine
Aminoisobutyric Acids - pharmacology
Aminoisobutyric Acids - urine
Animals
Biogenic Amines - urine
Blood Pressure - drug effects
Cross-Over Studies
Diet - methods
Female
Humans
Hypertension - chemically induced
Hypertension - diagnosis
Hypertension - physiopathology
Hypertension - urine
Male
Metabolome - drug effects
Middle Aged
Rats
Rats, Inbred Dahl
Research Paper
Sodium Chloride, Dietary - administration & dosage
Sodium Chloride, Dietary - antagonists & inhibitors
Sodium Chloride, Dietary - urine
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Summary:Dietary salt intake has significant effects on arterial blood pressure and the development of hypertension. Mechanisms underlying salt-dependent changes in blood pressure remain poorly understood, and it is difficult to assess blood pressure salt-sensitivity clinically. We examined urinary levels of metabolites in 103 participants of the Dietary Approaches to Stop Hypertension (DASH)-Sodium trial after nearly 30 days on a defined diet containing high sodium (targeting 150 mmol sodium intake per day) or low sodium (50 mmol per day). Targeted chromatography/mass spectrometry analysis was performed in 24 h urine samples for 47 amino metabolites and 10 metabolites related to the tricarboxylic acid cycle. The effect of an identified metabolite on blood pressure was examined in Dahl salt-sensitive rats. Urinary metabolite levels improved the prediction of classification of blood pressure salt-sensitivity based on race, age and sex. Random forest and generalized linear mixed model analyses identified significant (false discovery rate
ISSN:1838-7640
1838-7640
DOI:10.7150/thno.22018