SnapShot: Chronic Lymphocytic Leukemia

Despite the recent advances in the therapeutic management of Chronic Lymphocytic Leukemia (CLL) patients, this common B cell malignancy still remains incurable. This SnapShot provides an overview of CLL biology and therapy, with a focus on genetics and microenvironmental interactions, which contribu...

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Bibliographic Details
Published in:Cancer cell 2017-11, Vol.32 (5), p.716-716.e1
Main Authors: ten Hacken, Elisa, Guièze, Romain, Wu, Catherine J.
Format: Article
Language:English
Subjects:
B-Lymphocytes - metabolism
B-Lymphocytes - pathology
Disease Progression
Genetic Predisposition to Disease - genetics
Hematology
Human health and pathology
Humans
Leukemia, Lymphocytic, Chronic, B-Cell - genetics
Leukemia, Lymphocytic, Chronic, B-Cell - pathology
Leukemia, Lymphocytic, Chronic, B-Cell - therapy
Life Sciences
Models, Genetic
Mutation
Signal Transduction - genetics
Tumor Microenvironment - genetics
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Description
Summary:Despite the recent advances in the therapeutic management of Chronic Lymphocytic Leukemia (CLL) patients, this common B cell malignancy still remains incurable. This SnapShot provides an overview of CLL biology and therapy, with a focus on genetics and microenvironmental interactions, which contribute to disease progression and therapy resistance. To view this SnapShot, open or download the PDF. Despite the recent advances in the therapeutic management of Chronic Lymphocytic Leukemia (CLL) patients, this common B cell malignancy still remains incurable. This SnapShot provides an overview of CLL biology and therapy, with a focus on genetics and microenvironmental interactions, which contribute to disease progression and therapy resistance. To view this SnapShot, open or download the PDF.
ISSN:1535-6108
1878-3686
DOI:10.1016/j.ccell.2017.10.015