GEPSI: A Gene Expression Profile Similarity-Based Identification Method of Bioactive Components in Traditional Chinese Medicine Formula

The identification of bioactive components in traditional Chinese medicine (TCM) is an important part of the TCM material foundation research. Recently, molecular docking technology has been extensively used for the identification of TCM bioactive components. However, target proteins that are used i...

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Published in:Evidence-based complementary and alternative medicine 2018-01, Vol.2018 (2018), p.1-9
Main Authors: Zhang, Yanling, Lv, Chenyang, He, Shuaibing, Zhang, Bai-xia, Wang, Yun
Format: Article
Language:English
Subjects:
Analysis
Bioinformatics
Breast cancer
Cancer therapies
Chinese medicine
Component reliability
Disease
Drugs
Gene expression
Genes
Hypothesis testing
Identification
Medical research
Medicine, Chinese
Methods
Pharmaceutical sciences
Proteins
Traditional Chinese medicine
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creator Zhang, Yanling
Lv, Chenyang
He, Shuaibing
Zhang, Bai-xia
Wang, Yun
description The identification of bioactive components in traditional Chinese medicine (TCM) is an important part of the TCM material foundation research. Recently, molecular docking technology has been extensively used for the identification of TCM bioactive components. However, target proteins that are used in molecular docking may not be the actual TCM target. For this reason, the bioactive components would likely be omitted or incorrect. To address this problem, this study proposed the GEPSI method that identified the target proteins of TCM based on the similarity of gene expression profiles. The similarity of the gene expression profiles affected by TCM and small molecular drugs was calculated. The pharmacological action of TCM may be similar to that of small molecule drugs that have a high similarity score. Indeed, the target proteins of the small molecule drugs could be considered TCM targets. Thus, we identified the bioactive components of a TCM by molecular docking and verified the reliability of this method by a literature investigation. Using the target proteins that TCM actually affected as targets, the identification of the bioactive components was more accurate. This study provides a fast and effective method for the identification of TCM bioactive components.
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subjects Analysis
Bioinformatics
Breast cancer
Cancer therapies
Chinese medicine
Component reliability
Disease
Drugs
Gene expression
Genes
Hypothesis testing
Identification
Medical research
Medicine, Chinese
Methods
Pharmaceutical sciences
Proteins
Traditional Chinese medicine
title GEPSI: A Gene Expression Profile Similarity-Based Identification Method of Bioactive Components in Traditional Chinese Medicine Formula
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