Elevated Soluble Vascular Cell Adhesion Molecule-1 Is Associated With Cerebrovascular Resistance and Cognitive Function

Elevated plasma soluble vascular cell adhesion molecule-1 (sVCAM-1) is a presumed marker of endothelial dysfunction, both in the brain and systemic circulation. Impairments in memory and cognition have been associated with cardiovascular diseases, but little is known about their relationships to abn...

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Published in:The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2017-04, Vol.72 (4), p.560-566
Main Authors: Tchalla, Achille E, Wellenius, Gregory A, Sorond, Farzaneh A, Gagnon, Margaret, Iloputaife, Ikechukwu, Travison, Thomas G, Dantoine, Thierry, Lipsitz, Lewis A
Format: Article
Language:English
Subjects:
Aged
Blood Flow Velocity
Brain
Cardiovascular disease
Cell adhesion & migration
Cerebrovascular Circulation
Cognition
Cognition & reasoning
Cognition Disorders - blood
Cognition Disorders - physiopathology
Cross-Sectional Studies
Female
Geriatry and gerontology
Human health and pathology
Humans
Life Sciences
Male
Memory
Older people
Vascular Cell Adhesion Molecule-1 - blood
Vascular Resistance
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Summary:Elevated plasma soluble vascular cell adhesion molecule-1 (sVCAM-1) is a presumed marker of endothelial dysfunction, both in the brain and systemic circulation. Impairments in memory and cognition have been associated with cardiovascular diseases, but little is known about their relationships to abnormal cerebral endothelial function. We studied the cross-sectional association between sVCAM-1 and markers of cerebrovascular hemodynamics and cognitive function in 680 community-dwelling participants in the MOBILIZE Boston Study, aged 65 years and older. Cognitive function was assessed using the Hopkins Verbal Learning Memory Test and Trail Making Tests (TMTs) A and B. Global cognitive impairment was defined as Mini-Mental State Examination (MMSE) score less than 24. sVCAM-1 was measured by ELISA assay. Beat-to-beat blood flow velocity (BFV) and cerebrovascular resistance (CVR = mean arterial pressure / BFV) in the middle cerebral artery were assessed at rest by transcranial Doppler ultrasound. sVCAM-1 concentrations were higher among participants with an MMSE score
ISSN:1079-5006
1758-535X
1758-535X
DOI:10.1093/gerona/glw099