Immunomodulator effect of topical zinc oxide application in tuberculin skin test

We aimed to evaluate the sensitivity of tuberculin skintest (purified protein derivative-PPD) by topical zinc application on test site to improve diagnostic reliability. We performed this study in 100 children aged 6-14 years, and plasma zinc levels were analyzed after 10-12 hours fasting. After PPD...

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Bibliographic Details
Published in:Northern clinics of Istanbul 2018-01, Vol.5 (1), p.37-40
Main Authors: Nuhoglu, Cagatay, Hepkaya, Evrim, Onal, Zehra Esra, Akici, Narin, Gurbuz, Tamay, Atasayan, Vildan, Ceran, Omer
Format: Article
Language:English
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Original
purified protein derivative
tuberculin skin test
zinc
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Summary:We aimed to evaluate the sensitivity of tuberculin skintest (purified protein derivative-PPD) by topical zinc application on test site to improve diagnostic reliability. We performed this study in 100 children aged 6-14 years, and plasma zinc levels were analyzed after 10-12 hours fasting. After PPD, we applied 40% zinc oxide cream on one forearm and placebo on the other forearm. PPD indurations were measured 72 hours later. In this study, 26% of the children showed increases in PPD induration following local zinc applications. There was no correlation between indurations size and serum zinc levels. We concluded that topical zinc cream application can enhance sensitivity of tuberculin reactivityin the diagnosis of tuberculosis.
ISSN:2536-4553
2536-4553
2148-4902
DOI:10.14744/nci.2017.88896