Effects of Bariatric Surgery in Obese Patients With Hypertension: The GATEWAY Randomized Trial (Gastric Bypass to Treat Obese Patients With Steady Hypertension)

• Published in: Circulation (New York, N.Y.) N.Y.), 2018-03, Vol.137 (11), p.1132-1142
• Main Authors: Schiavon, Carlos Aurelio, Bersch-Ferreira, Angela Cristine, Santucci, Eliana Vieira, Oliveira, Juliana Dantas, Torreglosa, Camila Ragne, Bueno, Priscila Torres, Frayha, Julia Caldas, Santos, Renato Nakagawa, Damiani, Lucas Petri, Noujaim, Patricia Malvina, Halpern, Helio, Monteiro, Frederico L.J, Cohen, Ricardo Vitor, Uchoa, Carlos H, de Souza, Marcio Gonçalves, Amodeo, Celso, Bortolotto, Luiz, Ikeoka, Dimas, Drager, Luciano F, Cavalcanti, Alexandre Biasi, Berwanger, Otavio
• Format: Article
• Language: English
• Subjects: Adult; Antihypertensive Agents - therapeutic use; Blood Pressure - drug effects; Body Mass Index; Brazil; Female; Gastric Bypass - adverse effects; Humans; Hypertension - diagnosis; Hypertension - drug therapy; Hypertension - physiopathology; Male; Middle Aged; Obesity - diagnosis; Obesity - physiopathology; Obesity - surgery; Original s; Time Factors; Treatment Outcome; Weight Loss
• ISSN: 0009-7322; 1524-4539; 1524-4539
• DOI: 10.1161/CIRCULATIONAHA.117.032130

BACKGROUND:Recent research efforts on bariatric surgery have focused on metabolic and diabetes mellitus resolution. Randomized trials designed to assess the impact of bariatric surgery in patients with obesity and hypertension are needed. METHODS:In this randomized, single-center, nonblinded trial, we included patients with hypertension (using ≥2 medications at maximum doses or >2 at moderate doses) and a body mass index between 30.0 and 39.9 kg/m. Patients were randomized to Roux-en-Y gastric bypass plus medical therapy or medical therapy alone. The primary end point was reduction of ≥30% of the total number of antihypertensive medications while maintaining systolic and diastolic blood pressure