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Resveratrol and pinostilbene confer neuroprotection against aging-related deficits through an ERK1/2-dependent mechanism
Age-related declines in motor function may be due, in part, to an increase in oxidative stress in the aging brain leading to dopamine (DA) neuronal cell death. In this study, we examined the neuroprotective effects of natural antioxidants resveratrol and pinostilbene against age-related DAergic cell...
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Published in: | The Journal of nutritional biochemistry 2018-04, Vol.54, p.77-86 |
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creator | Allen, Erika N. Potdar, Sneha Tapias, Victor Parmar, Mayur Mizuno, Cassia S. Rimando, Agnes Cavanaugh, Jane E. |
description | Age-related declines in motor function may be due, in part, to an increase in oxidative stress in the aging brain leading to dopamine (DA) neuronal cell death. In this study, we examined the neuroprotective effects of natural antioxidants resveratrol and pinostilbene against age-related DAergic cell death and motor dysfunction using SH-SY5Y neuroblastoma cells and young, middle-aged, and old male C57BL/6 mice. Resveratrol and pinostilbene protected SH-SY5Y cells from a DA-induced decrease in cell viability. Dietary supplementation with resveratrol and pinostilbene inhibited the decline of motor function observed with age. While DA and its metabolites (DOPAC and HVA), dopamine transporter, and tyrosine hydroxylase levels remain unchanged during aging or treatment, resveratrol and pinostilbene increased ERK1/2 activation in vitro and in vivo in an age-dependent manner. Inhibition of ERK1/2 in SH-SY5Y cells decreased the protective effects of both compounds. These data suggest that resveratrol and pinostilbene alleviate age-related motor decline via the promotion of DA neuronal survival and activation of the ERK1/2 pathways. |
doi_str_mv | 10.1016/j.jnutbio.2017.10.015 |
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In this study, we examined the neuroprotective effects of natural antioxidants resveratrol and pinostilbene against age-related DAergic cell death and motor dysfunction using SH-SY5Y neuroblastoma cells and young, middle-aged, and old male C57BL/6 mice. Resveratrol and pinostilbene protected SH-SY5Y cells from a DA-induced decrease in cell viability. Dietary supplementation with resveratrol and pinostilbene inhibited the decline of motor function observed with age. While DA and its metabolites (DOPAC and HVA), dopamine transporter, and tyrosine hydroxylase levels remain unchanged during aging or treatment, resveratrol and pinostilbene increased ERK1/2 activation in vitro and in vivo in an age-dependent manner. Inhibition of ERK1/2 in SH-SY5Y cells decreased the protective effects of both compounds. These data suggest that resveratrol and pinostilbene alleviate age-related motor decline via the promotion of DA neuronal survival and activation of the ERK1/2 pathways.</description><identifier>ISSN: 0955-2863</identifier><identifier>EISSN: 1873-4847</identifier><identifier>DOI: 10.1016/j.jnutbio.2017.10.015</identifier><identifier>PMID: 29268122</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aging ; antioxidants ; brain ; cell death ; cell viability ; dietary supplements ; dopamine ; ERK1/2 ; males ; metabolites ; mice ; neurons ; neuroprotective effect ; oxidative stress ; Pinostilbene ; Resveratrol ; senescence (aging) ; SH-SY5Y ; Striatum ; Substantia nigra ; transporters ; tyrosine 3-monooxygenase</subject><ispartof>The Journal of nutritional biochemistry, 2018-04, Vol.54, p.77-86</ispartof><rights>2017 Elsevier Inc.</rights><rights>Copyright © 2017 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c500t-c950c8cdee7e6ee281e3c1663572785d36e3385a51346a1d042fce0f268a56903</citedby><cites>FETCH-LOGICAL-c500t-c950c8cdee7e6ee281e3c1663572785d36e3385a51346a1d042fce0f268a56903</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,778,782,883,27911,27912</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29268122$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Allen, Erika N.</creatorcontrib><creatorcontrib>Potdar, Sneha</creatorcontrib><creatorcontrib>Tapias, Victor</creatorcontrib><creatorcontrib>Parmar, Mayur</creatorcontrib><creatorcontrib>Mizuno, Cassia S.</creatorcontrib><creatorcontrib>Rimando, Agnes</creatorcontrib><creatorcontrib>Cavanaugh, Jane E.</creatorcontrib><title>Resveratrol and pinostilbene confer neuroprotection against aging-related deficits through an ERK1/2-dependent mechanism</title><title>The Journal of nutritional biochemistry</title><addtitle>J Nutr Biochem</addtitle><description>Age-related declines in motor function may be due, in part, to an increase in oxidative stress in the aging brain leading to dopamine (DA) neuronal cell death. In this study, we examined the neuroprotective effects of natural antioxidants resveratrol and pinostilbene against age-related DAergic cell death and motor dysfunction using SH-SY5Y neuroblastoma cells and young, middle-aged, and old male C57BL/6 mice. Resveratrol and pinostilbene protected SH-SY5Y cells from a DA-induced decrease in cell viability. Dietary supplementation with resveratrol and pinostilbene inhibited the decline of motor function observed with age. While DA and its metabolites (DOPAC and HVA), dopamine transporter, and tyrosine hydroxylase levels remain unchanged during aging or treatment, resveratrol and pinostilbene increased ERK1/2 activation in vitro and in vivo in an age-dependent manner. Inhibition of ERK1/2 in SH-SY5Y cells decreased the protective effects of both compounds. These data suggest that resveratrol and pinostilbene alleviate age-related motor decline via the promotion of DA neuronal survival and activation of the ERK1/2 pathways.</description><subject>Aging</subject><subject>antioxidants</subject><subject>brain</subject><subject>cell death</subject><subject>cell viability</subject><subject>dietary supplements</subject><subject>dopamine</subject><subject>ERK1/2</subject><subject>males</subject><subject>metabolites</subject><subject>mice</subject><subject>neurons</subject><subject>neuroprotective effect</subject><subject>oxidative stress</subject><subject>Pinostilbene</subject><subject>Resveratrol</subject><subject>senescence (aging)</subject><subject>SH-SY5Y</subject><subject>Striatum</subject><subject>Substantia nigra</subject><subject>transporters</subject><subject>tyrosine 3-monooxygenase</subject><issn>0955-2863</issn><issn>1873-4847</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNqFkU1vEzEQhi0EomnhJ4B85LKpP9Ze7wWEqkIRlZAqOFuOPZs42rUX2xvBv8dRQgWnnkaaeeedjwehN5SsKaHyer_eh6VsfFwzQruaWxMqnqEVVR1vWtV2z9GK9EI0TEl-gS5z3hNCWCvkS3TBeiYVZWyFfj1APkAyJcURm-Dw7EPMxY8bCIBtDAMkHGBJcU6xgC0-Bmy2xodcavRh2yQYTQGHHQze-pJx2aW4bHfVDt8-fKXXrHEwQ3AQCp7A7kzweXqFXgxmzPD6HK_Qj0-332_umvtvn7_cfLxvrCCkNLYXxCrrADqQAExR4JZKyUXHOiUcl8C5EkZQ3kpDHWnZYIEM9T4jZE_4FXp_8p2XzQTO1iWSGfWc_GTSbx2N1_9Xgt_pbTxooaTsJKsG784GKf5cIBc9-WxhHE2AuGTNCCNKijr-SSntu76XrSBHV3GS2hRzTjA8bkSJPgLWe30GrI-Aj-kKuPa9_fecx66_RKvgw0kA9akHD0ln6yFYcD5VfNpF_8SIPxa5vK8</recordid><startdate>20180401</startdate><enddate>20180401</enddate><creator>Allen, Erika N.</creator><creator>Potdar, Sneha</creator><creator>Tapias, Victor</creator><creator>Parmar, Mayur</creator><creator>Mizuno, Cassia S.</creator><creator>Rimando, Agnes</creator><creator>Cavanaugh, Jane E.</creator><general>Elsevier Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope></search><sort><creationdate>20180401</creationdate><title>Resveratrol and pinostilbene confer neuroprotection against aging-related deficits through an ERK1/2-dependent mechanism</title><author>Allen, Erika N. ; Potdar, Sneha ; Tapias, Victor ; Parmar, Mayur ; Mizuno, Cassia S. ; Rimando, Agnes ; Cavanaugh, Jane E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c500t-c950c8cdee7e6ee281e3c1663572785d36e3385a51346a1d042fce0f268a56903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aging</topic><topic>antioxidants</topic><topic>brain</topic><topic>cell death</topic><topic>cell viability</topic><topic>dietary supplements</topic><topic>dopamine</topic><topic>ERK1/2</topic><topic>males</topic><topic>metabolites</topic><topic>mice</topic><topic>neurons</topic><topic>neuroprotective effect</topic><topic>oxidative stress</topic><topic>Pinostilbene</topic><topic>Resveratrol</topic><topic>senescence (aging)</topic><topic>SH-SY5Y</topic><topic>Striatum</topic><topic>Substantia nigra</topic><topic>transporters</topic><topic>tyrosine 3-monooxygenase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Allen, Erika N.</creatorcontrib><creatorcontrib>Potdar, Sneha</creatorcontrib><creatorcontrib>Tapias, Victor</creatorcontrib><creatorcontrib>Parmar, Mayur</creatorcontrib><creatorcontrib>Mizuno, Cassia S.</creatorcontrib><creatorcontrib>Rimando, Agnes</creatorcontrib><creatorcontrib>Cavanaugh, Jane E.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of nutritional biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Allen, Erika N.</au><au>Potdar, Sneha</au><au>Tapias, Victor</au><au>Parmar, Mayur</au><au>Mizuno, Cassia S.</au><au>Rimando, Agnes</au><au>Cavanaugh, Jane E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Resveratrol and pinostilbene confer neuroprotection against aging-related deficits through an ERK1/2-dependent mechanism</atitle><jtitle>The Journal of nutritional biochemistry</jtitle><addtitle>J Nutr Biochem</addtitle><date>2018-04-01</date><risdate>2018</risdate><volume>54</volume><spage>77</spage><epage>86</epage><pages>77-86</pages><issn>0955-2863</issn><eissn>1873-4847</eissn><abstract>Age-related declines in motor function may be due, in part, to an increase in oxidative stress in the aging brain leading to dopamine (DA) neuronal cell death. 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subjects | Aging antioxidants brain cell death cell viability dietary supplements dopamine ERK1/2 males metabolites mice neurons neuroprotective effect oxidative stress Pinostilbene Resveratrol senescence (aging) SH-SY5Y Striatum Substantia nigra transporters tyrosine 3-monooxygenase |
title | Resveratrol and pinostilbene confer neuroprotection against aging-related deficits through an ERK1/2-dependent mechanism |
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