Loading…

Resveratrol and pinostilbene confer neuroprotection against aging-related deficits through an ERK1/2-dependent mechanism

Age-related declines in motor function may be due, in part, to an increase in oxidative stress in the aging brain leading to dopamine (DA) neuronal cell death. In this study, we examined the neuroprotective effects of natural antioxidants resveratrol and pinostilbene against age-related DAergic cell...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of nutritional biochemistry 2018-04, Vol.54, p.77-86
Main Authors: Allen, Erika N., Potdar, Sneha, Tapias, Victor, Parmar, Mayur, Mizuno, Cassia S., Rimando, Agnes, Cavanaugh, Jane E.
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c500t-c950c8cdee7e6ee281e3c1663572785d36e3385a51346a1d042fce0f268a56903
cites cdi_FETCH-LOGICAL-c500t-c950c8cdee7e6ee281e3c1663572785d36e3385a51346a1d042fce0f268a56903
container_end_page 86
container_issue
container_start_page 77
container_title The Journal of nutritional biochemistry
container_volume 54
creator Allen, Erika N.
Potdar, Sneha
Tapias, Victor
Parmar, Mayur
Mizuno, Cassia S.
Rimando, Agnes
Cavanaugh, Jane E.
description Age-related declines in motor function may be due, in part, to an increase in oxidative stress in the aging brain leading to dopamine (DA) neuronal cell death. In this study, we examined the neuroprotective effects of natural antioxidants resveratrol and pinostilbene against age-related DAergic cell death and motor dysfunction using SH-SY5Y neuroblastoma cells and young, middle-aged, and old male C57BL/6 mice. Resveratrol and pinostilbene protected SH-SY5Y cells from a DA-induced decrease in cell viability. Dietary supplementation with resveratrol and pinostilbene inhibited the decline of motor function observed with age. While DA and its metabolites (DOPAC and HVA), dopamine transporter, and tyrosine hydroxylase levels remain unchanged during aging or treatment, resveratrol and pinostilbene increased ERK1/2 activation in vitro and in vivo in an age-dependent manner. Inhibition of ERK1/2 in SH-SY5Y cells decreased the protective effects of both compounds. These data suggest that resveratrol and pinostilbene alleviate age-related motor decline via the promotion of DA neuronal survival and activation of the ERK1/2 pathways.
doi_str_mv 10.1016/j.jnutbio.2017.10.015
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5866762</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0955286317301407</els_id><sourcerecordid>1979964502</sourcerecordid><originalsourceid>FETCH-LOGICAL-c500t-c950c8cdee7e6ee281e3c1663572785d36e3385a51346a1d042fce0f268a56903</originalsourceid><addsrcrecordid>eNqFkU1vEzEQhi0EomnhJ4B85LKpP9Ze7wWEqkIRlZAqOFuOPZs42rUX2xvBv8dRQgWnnkaaeeedjwehN5SsKaHyer_eh6VsfFwzQruaWxMqnqEVVR1vWtV2z9GK9EI0TEl-gS5z3hNCWCvkS3TBeiYVZWyFfj1APkAyJcURm-Dw7EPMxY8bCIBtDAMkHGBJcU6xgC0-Bmy2xodcavRh2yQYTQGHHQze-pJx2aW4bHfVDt8-fKXXrHEwQ3AQCp7A7kzweXqFXgxmzPD6HK_Qj0-332_umvtvn7_cfLxvrCCkNLYXxCrrADqQAExR4JZKyUXHOiUcl8C5EkZQ3kpDHWnZYIEM9T4jZE_4FXp_8p2XzQTO1iWSGfWc_GTSbx2N1_9Xgt_pbTxooaTsJKsG784GKf5cIBc9-WxhHE2AuGTNCCNKijr-SSntu76XrSBHV3GS2hRzTjA8bkSJPgLWe30GrI-Aj-kKuPa9_fecx66_RKvgw0kA9akHD0ln6yFYcD5VfNpF_8SIPxa5vK8</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1979964502</pqid></control><display><type>article</type><title>Resveratrol and pinostilbene confer neuroprotection against aging-related deficits through an ERK1/2-dependent mechanism</title><source>ScienceDirect Freedom Collection</source><creator>Allen, Erika N. ; Potdar, Sneha ; Tapias, Victor ; Parmar, Mayur ; Mizuno, Cassia S. ; Rimando, Agnes ; Cavanaugh, Jane E.</creator><creatorcontrib>Allen, Erika N. ; Potdar, Sneha ; Tapias, Victor ; Parmar, Mayur ; Mizuno, Cassia S. ; Rimando, Agnes ; Cavanaugh, Jane E.</creatorcontrib><description>Age-related declines in motor function may be due, in part, to an increase in oxidative stress in the aging brain leading to dopamine (DA) neuronal cell death. In this study, we examined the neuroprotective effects of natural antioxidants resveratrol and pinostilbene against age-related DAergic cell death and motor dysfunction using SH-SY5Y neuroblastoma cells and young, middle-aged, and old male C57BL/6 mice. Resveratrol and pinostilbene protected SH-SY5Y cells from a DA-induced decrease in cell viability. Dietary supplementation with resveratrol and pinostilbene inhibited the decline of motor function observed with age. While DA and its metabolites (DOPAC and HVA), dopamine transporter, and tyrosine hydroxylase levels remain unchanged during aging or treatment, resveratrol and pinostilbene increased ERK1/2 activation in vitro and in vivo in an age-dependent manner. Inhibition of ERK1/2 in SH-SY5Y cells decreased the protective effects of both compounds. These data suggest that resveratrol and pinostilbene alleviate age-related motor decline via the promotion of DA neuronal survival and activation of the ERK1/2 pathways.</description><identifier>ISSN: 0955-2863</identifier><identifier>EISSN: 1873-4847</identifier><identifier>DOI: 10.1016/j.jnutbio.2017.10.015</identifier><identifier>PMID: 29268122</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aging ; antioxidants ; brain ; cell death ; cell viability ; dietary supplements ; dopamine ; ERK1/2 ; males ; metabolites ; mice ; neurons ; neuroprotective effect ; oxidative stress ; Pinostilbene ; Resveratrol ; senescence (aging) ; SH-SY5Y ; Striatum ; Substantia nigra ; transporters ; tyrosine 3-monooxygenase</subject><ispartof>The Journal of nutritional biochemistry, 2018-04, Vol.54, p.77-86</ispartof><rights>2017 Elsevier Inc.</rights><rights>Copyright © 2017 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c500t-c950c8cdee7e6ee281e3c1663572785d36e3385a51346a1d042fce0f268a56903</citedby><cites>FETCH-LOGICAL-c500t-c950c8cdee7e6ee281e3c1663572785d36e3385a51346a1d042fce0f268a56903</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,778,782,883,27911,27912</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29268122$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Allen, Erika N.</creatorcontrib><creatorcontrib>Potdar, Sneha</creatorcontrib><creatorcontrib>Tapias, Victor</creatorcontrib><creatorcontrib>Parmar, Mayur</creatorcontrib><creatorcontrib>Mizuno, Cassia S.</creatorcontrib><creatorcontrib>Rimando, Agnes</creatorcontrib><creatorcontrib>Cavanaugh, Jane E.</creatorcontrib><title>Resveratrol and pinostilbene confer neuroprotection against aging-related deficits through an ERK1/2-dependent mechanism</title><title>The Journal of nutritional biochemistry</title><addtitle>J Nutr Biochem</addtitle><description>Age-related declines in motor function may be due, in part, to an increase in oxidative stress in the aging brain leading to dopamine (DA) neuronal cell death. In this study, we examined the neuroprotective effects of natural antioxidants resveratrol and pinostilbene against age-related DAergic cell death and motor dysfunction using SH-SY5Y neuroblastoma cells and young, middle-aged, and old male C57BL/6 mice. Resveratrol and pinostilbene protected SH-SY5Y cells from a DA-induced decrease in cell viability. Dietary supplementation with resveratrol and pinostilbene inhibited the decline of motor function observed with age. While DA and its metabolites (DOPAC and HVA), dopamine transporter, and tyrosine hydroxylase levels remain unchanged during aging or treatment, resveratrol and pinostilbene increased ERK1/2 activation in vitro and in vivo in an age-dependent manner. Inhibition of ERK1/2 in SH-SY5Y cells decreased the protective effects of both compounds. These data suggest that resveratrol and pinostilbene alleviate age-related motor decline via the promotion of DA neuronal survival and activation of the ERK1/2 pathways.</description><subject>Aging</subject><subject>antioxidants</subject><subject>brain</subject><subject>cell death</subject><subject>cell viability</subject><subject>dietary supplements</subject><subject>dopamine</subject><subject>ERK1/2</subject><subject>males</subject><subject>metabolites</subject><subject>mice</subject><subject>neurons</subject><subject>neuroprotective effect</subject><subject>oxidative stress</subject><subject>Pinostilbene</subject><subject>Resveratrol</subject><subject>senescence (aging)</subject><subject>SH-SY5Y</subject><subject>Striatum</subject><subject>Substantia nigra</subject><subject>transporters</subject><subject>tyrosine 3-monooxygenase</subject><issn>0955-2863</issn><issn>1873-4847</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNqFkU1vEzEQhi0EomnhJ4B85LKpP9Ze7wWEqkIRlZAqOFuOPZs42rUX2xvBv8dRQgWnnkaaeeedjwehN5SsKaHyer_eh6VsfFwzQruaWxMqnqEVVR1vWtV2z9GK9EI0TEl-gS5z3hNCWCvkS3TBeiYVZWyFfj1APkAyJcURm-Dw7EPMxY8bCIBtDAMkHGBJcU6xgC0-Bmy2xodcavRh2yQYTQGHHQze-pJx2aW4bHfVDt8-fKXXrHEwQ3AQCp7A7kzweXqFXgxmzPD6HK_Qj0-332_umvtvn7_cfLxvrCCkNLYXxCrrADqQAExR4JZKyUXHOiUcl8C5EkZQ3kpDHWnZYIEM9T4jZE_4FXp_8p2XzQTO1iWSGfWc_GTSbx2N1_9Xgt_pbTxooaTsJKsG784GKf5cIBc9-WxhHE2AuGTNCCNKijr-SSntu76XrSBHV3GS2hRzTjA8bkSJPgLWe30GrI-Aj-kKuPa9_fecx66_RKvgw0kA9akHD0ln6yFYcD5VfNpF_8SIPxa5vK8</recordid><startdate>20180401</startdate><enddate>20180401</enddate><creator>Allen, Erika N.</creator><creator>Potdar, Sneha</creator><creator>Tapias, Victor</creator><creator>Parmar, Mayur</creator><creator>Mizuno, Cassia S.</creator><creator>Rimando, Agnes</creator><creator>Cavanaugh, Jane E.</creator><general>Elsevier Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope></search><sort><creationdate>20180401</creationdate><title>Resveratrol and pinostilbene confer neuroprotection against aging-related deficits through an ERK1/2-dependent mechanism</title><author>Allen, Erika N. ; Potdar, Sneha ; Tapias, Victor ; Parmar, Mayur ; Mizuno, Cassia S. ; Rimando, Agnes ; Cavanaugh, Jane E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c500t-c950c8cdee7e6ee281e3c1663572785d36e3385a51346a1d042fce0f268a56903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aging</topic><topic>antioxidants</topic><topic>brain</topic><topic>cell death</topic><topic>cell viability</topic><topic>dietary supplements</topic><topic>dopamine</topic><topic>ERK1/2</topic><topic>males</topic><topic>metabolites</topic><topic>mice</topic><topic>neurons</topic><topic>neuroprotective effect</topic><topic>oxidative stress</topic><topic>Pinostilbene</topic><topic>Resveratrol</topic><topic>senescence (aging)</topic><topic>SH-SY5Y</topic><topic>Striatum</topic><topic>Substantia nigra</topic><topic>transporters</topic><topic>tyrosine 3-monooxygenase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Allen, Erika N.</creatorcontrib><creatorcontrib>Potdar, Sneha</creatorcontrib><creatorcontrib>Tapias, Victor</creatorcontrib><creatorcontrib>Parmar, Mayur</creatorcontrib><creatorcontrib>Mizuno, Cassia S.</creatorcontrib><creatorcontrib>Rimando, Agnes</creatorcontrib><creatorcontrib>Cavanaugh, Jane E.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of nutritional biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Allen, Erika N.</au><au>Potdar, Sneha</au><au>Tapias, Victor</au><au>Parmar, Mayur</au><au>Mizuno, Cassia S.</au><au>Rimando, Agnes</au><au>Cavanaugh, Jane E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Resveratrol and pinostilbene confer neuroprotection against aging-related deficits through an ERK1/2-dependent mechanism</atitle><jtitle>The Journal of nutritional biochemistry</jtitle><addtitle>J Nutr Biochem</addtitle><date>2018-04-01</date><risdate>2018</risdate><volume>54</volume><spage>77</spage><epage>86</epage><pages>77-86</pages><issn>0955-2863</issn><eissn>1873-4847</eissn><abstract>Age-related declines in motor function may be due, in part, to an increase in oxidative stress in the aging brain leading to dopamine (DA) neuronal cell death. In this study, we examined the neuroprotective effects of natural antioxidants resveratrol and pinostilbene against age-related DAergic cell death and motor dysfunction using SH-SY5Y neuroblastoma cells and young, middle-aged, and old male C57BL/6 mice. Resveratrol and pinostilbene protected SH-SY5Y cells from a DA-induced decrease in cell viability. Dietary supplementation with resveratrol and pinostilbene inhibited the decline of motor function observed with age. While DA and its metabolites (DOPAC and HVA), dopamine transporter, and tyrosine hydroxylase levels remain unchanged during aging or treatment, resveratrol and pinostilbene increased ERK1/2 activation in vitro and in vivo in an age-dependent manner. Inhibition of ERK1/2 in SH-SY5Y cells decreased the protective effects of both compounds. These data suggest that resveratrol and pinostilbene alleviate age-related motor decline via the promotion of DA neuronal survival and activation of the ERK1/2 pathways.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>29268122</pmid><doi>10.1016/j.jnutbio.2017.10.015</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0955-2863
ispartof The Journal of nutritional biochemistry, 2018-04, Vol.54, p.77-86
issn 0955-2863
1873-4847
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5866762
source ScienceDirect Freedom Collection
subjects Aging
antioxidants
brain
cell death
cell viability
dietary supplements
dopamine
ERK1/2
males
metabolites
mice
neurons
neuroprotective effect
oxidative stress
Pinostilbene
Resveratrol
senescence (aging)
SH-SY5Y
Striatum
Substantia nigra
transporters
tyrosine 3-monooxygenase
title Resveratrol and pinostilbene confer neuroprotection against aging-related deficits through an ERK1/2-dependent mechanism
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T16%3A19%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Resveratrol%20and%20pinostilbene%20confer%20neuroprotection%20against%20aging-related%20deficits%20through%20an%20ERK1/2-dependent%20mechanism&rft.jtitle=The%20Journal%20of%20nutritional%20biochemistry&rft.au=Allen,%20Erika%20N.&rft.date=2018-04-01&rft.volume=54&rft.spage=77&rft.epage=86&rft.pages=77-86&rft.issn=0955-2863&rft.eissn=1873-4847&rft_id=info:doi/10.1016/j.jnutbio.2017.10.015&rft_dat=%3Cproquest_pubme%3E1979964502%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c500t-c950c8cdee7e6ee281e3c1663572785d36e3385a51346a1d042fce0f268a56903%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1979964502&rft_id=info:pmid/29268122&rfr_iscdi=true