The relationship between myocardial fibrosis and myocardial microRNAs in dilated cardiomyopathy: A link between mir‐133a and cardiovascular events

• Published in: Journal of cellular and molecular medicine 2018-04, Vol.22 (4), p.2514-2517
• Main Authors: Rubiś, Paweł, Totoń‐Żurańska, Justyna, Wiśniowska‐Śmiałek, Sylwia, Dziewięcka, Ewa, Kołton‐Wróż, Maria, Wołkow, Paweł, Pitera, Ewelina, Rudnicka‐Sosin, Lucyna, Garlitski, Ann C., Gackowski, Andrzej, Podolec, Piotr
• Format: Article
• Language: English
• Subjects: Biomarkers - blood; Biopsy; Cardiomyopathy; Cardiomyopathy, Dilated - blood; Cardiomyopathy, Dilated - genetics; Cardiomyopathy, Dilated - physiopathology; Dilated cardiomyopathy; Extracellular matrix; Extracellular Matrix - genetics; Female; Fibrosis; Fibrosis - blood; Fibrosis - genetics; Fibrosis - physiopathology; Heart; Heart surgery; Heart Ventricles - metabolism; Heart Ventricles - pathology; Humans; Male; microRNA; MicroRNAs; MicroRNAs - blood; MicroRNAs - genetics; Middle Aged; miRNA; Myocardium - metabolism; Myocardium - pathology; prognosis; Short Communication; Short Communications; Ventricle
• ISSN: 1582-1838; 1582-4934
• DOI: 10.1111/jcmm.13535

It is unknown whether fibrosis‐associated microRNAs: miR‐21, miR‐26, miR‐29, miR‐30 and miR‐133a are linked to cardiovascular (CV) outcome. The study evaluated the levels of extracellular matrix (ECM) fibrosis and the prevalence of particular microRNAs in patients with dilated cardiomyopathy (DCM) to investigate any correlation with CV events. Methods: Seventy DCM patients (48 ± 12 years, EF 24.4 ± 7.4%) underwent right ventricular biopsy. The control group was comprised of 7 patients with CAD who underwent CABG and intraoperative biopsy. MicroRNAs were measured in blood and myocardial tissue via qPCR. The end‐point was a combination of CV death and urgent HF hospitalization at the end of 12 months. There were differential levels of circulating and myocardial miR‐26 and miR‐29 as well as myocardial miR‐133a when the DCM and CABG groups were compared. Corresponding circulating and myocardial microRNAs did not correlate with one another. There was no correlation between microRNA and ECM fibrosis. By the end of the 12‐month period of the study, CV death had occurred in 6 patients, and a further 19 patients required urgent HF hospitalization. None of the circulating microRNAs was a predictor of the combined end‐point; however, myocardial miR‐133a was an independent predictor in unadjusted models (HR 1.53; 95% CI 1.14‐2.05; P