Salivary Biomarkers in Systemic Sclerosis Disease

Scleroderma or systemic sclerosis (SSc) is frequently detected at an advanced stage due to diagnosis difficulties. Salivary biomarkers, if existing, could be used for predictive diagnosis of this disease. Human saliva contains a large number of proteins that can be used for diagnosis and are of grea...

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Bibliographic Details
Published in:BioMed research international 2018-01, Vol.2018 (2018), p.1-7
Main Authors: Ghailani Nourouti, Naima, Barakat, Amina, Bakkach, Joaira, Zian, Zeineb, Bennani Mechita, Mohcine
Format: Article
Language:English
Subjects:
Analysis
Biological markers
Biomarkers
Biomarkers - metabolism
Diagnosis
Diagnostic software
Diagnostic systems
Disease
Health aspects
Humans
Mass spectrometry
Medical research
Medicine, Experimental
Pathology
Proteins
Proteomics
Proteomics - methods
Review
Saliva
Saliva - metabolism
Salivary Proteins and Peptides - metabolism
Scientific imaging
Scleroderma
Scleroderma (Disease)
Scleroderma, Systemic - diagnosis
Scleroderma, Systemic - metabolism
Skin
Systemic scleroderma
Systemic sclerosis
Therapeutic applications
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Summary:Scleroderma or systemic sclerosis (SSc) is frequently detected at an advanced stage due to diagnosis difficulties. Salivary biomarkers, if existing, could be used for predictive diagnosis of this disease. Human saliva contains a large number of proteins that can be used for diagnosis and are of great potential in clinical research. The use of proteomic analysis to characterize whole saliva (WS) in SSc has gained an increasing attention in the last years and the identification of salivary proteins specific for SSc could lead to early diagnosis or new therapeutic targets. This review will present an overview about the use of WS in SSc studies. The proteomic technologies currently used for global identification of salivary proteins in SSc, as well as the advantages and limitations for the use of WS as a diagnostic tool, will be presented.
ISSN:2314-6133
2314-6141
DOI:10.1155/2018/3921247