Influence of optic disc-fovea distance on macular thickness measurements with OCT in healthy myopic eyes

• Published in: Scientific reports 2018-03, Vol.8 (1), p.5233-8, Article 5233
• Main Authors: Qiu, Kunliang, Wang, Geng, Zhang, Riping, Lu, Xuehui, Zhang, Mingzhi, Jansonius, Nomdo M.
• Format: Article
• Language: English
• Subjects: 59; 692/308/2778; 692/699/3161/3174; Adolescent; Adult; Age; Coma; Correlation analysis; Eye; Eye diseases; Female; Fovea Centralis - diagnostic imaging; Gender; Humanities and Social Sciences; Humans; Macula Lutea - diagnostic imaging; Male; multidisciplinary; Myopia - diagnostic imaging; Optic Disk - diagnostic imaging; Retina; Science; Science (multidisciplinary); Standard deviation; Tomography, Optical Coherence - methods; Young Adult
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-018-23479-z

Assessment of macular thickness is important in the evaluation of various eye diseases. This study aimed to determine the influence of the optic disc-fovea distance (DFD) on macular thickness in myopic eyes. We determined the DFD and the macular thickness in 138 eyes from 138 healthy myopic subjects using the Cirrus HD-OCT. Correlation analysis and multiple linear regression were performed to determine the influence of DFD, axial length, disc area, and β-PPA on macular thickness. To further remove the confounding effect of ocular magnification on the DFD and OCT scan area, a subgroup analysis was performed in eyes with a limited axial length range (24–25 mm). DFD was significantly correlated with both regional (central, inner, and outer ETDRS subfields) and overall average macular thickness at a Bonferroni corrected P value of 0.004 (r ranging from −0.27 to −0.47), except for the temporal outer (r = −0.15, P = 0.089) and inferior outer (r = −0.22, P = 0.011) macular thickness. In the multivariable analysis, DFD was significantly associated with the average inner and outer macular thickness, the central subfield thickness, and the overall macular thickness (all P