Ocimum gratissimum Ameliorates Gentamicin-Induced Kidney Injury but Decreases Creatinine Clearance Following Sub-Chronic Administration in Rats

The effects of aqueous extract of Ocimum gratissimum leaf (AOGL) on the renal function of rats with gentamicin-induced nephrotoxicity were investigated. This study involved the use of forty five (45) adult male Wistar rats (housed in separate metabolic cages) such that graded doses of OAGL were admi...

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Published in:Journal of evidence-based complementary & alternative medicine 2017-10, Vol.22 (4), p.592-602
Main Authors: Ogundipe, Dare J., Akomolafe, Rufus O., Sanusi, Abubakar A., Imafidon, Christian E., Olukiran, Olaoluwa S., Oladele, Ayowole A.
Format: Article
Language:English
Subjects:
Animals
Antioxidants
Creatinine - metabolism
Dosage
Food consumption
Gentamicins - toxicity
Glutathione - metabolism
Histology
Induced
Injuries
Kidney - drug effects
Kidney - pathology
Kidney - physiology
Male
Metabolic Clearance Rate
Ocimum
Original
Plant Extracts - pharmacology
Rats
Rats, Wistar
Urine
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Summary:The effects of aqueous extract of Ocimum gratissimum leaf (AOGL) on the renal function of rats with gentamicin-induced nephrotoxicity were investigated. This study involved the use of forty five (45) adult male Wistar rats (housed in separate metabolic cages) such that graded doses of OAGL were administered to the experimental groups (p.o.) for 28 days after exposure to gentamicin toxicity (100 mg/kg i.p.) for 1 week. At the end of the study, comparisons of some indices of renal function as well as antioxidant status (GSH and TBARS) were made between the control, toxic and AOGL-treated groups at P < 0.05. The result showed that gentamicin treatment caused significant increase (P < .05) in urine output, urea, creatinine, total protein, relative kidney weight, and TBARS, as well as significant decrease (P < .05) in urine creatinine and GSH levels. Post-treatment with graded doses of AOGL caused significant increase in food consumption, GSH, urine, and plasma creatinine, as well as significant decrease (P < .05) in relative kidney weight, TBARS, and urine total protein. There was an appreciable difference in the kidney histology of the AOGL-treated groups when compared with the toxic control. Hence, the extract has therapeutic potential in the management of gentamicin-induced kidney injury, although a risk profile of renal dysfunction is not unlikely from 28 days of administration as evident by the decrease in creatinine clearance.
ISSN:2156-5872
2156-5899
2515-690X
DOI:10.1177/2156587217691891